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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Adartm2Phs
targeted mutation 2, Peter H Seeburg
MGI:3029862
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Adartm2Phs/Adartm2Phs B6.Cg-Adartm2Phs MGI:3828310
hm2
 		Adartm2Phs/Adartm2Phs involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3029864
hm3
 		Adartm2Phs/Adartm2Phs involves: 129S1/Sv * 129X1/SvJ * NMRI MGI:3029865
cn4
 		Adartm1.1Phs/Adartm2Phs
Tg(Tal1-cre/ERT)42-056Jrg/? 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3843982
cn5
 		Adartm1.1Phs/Adartm2Phs
Tg(Mx1-cre)1Cgn/? 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA MGI:3828311


Genotype
MGI:3828310
hm1
Allelic
Composition		 Adartm2Phs/Adartm2Phs
Genetic
Background		 B6.Cg-Adartm2Phs
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adartm2Phs mutation (0 available); any Adar mutation (72 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal hematopoietic stem cell morphology ( J:142338 )
• the frequency and absolute number of Lin- c-Kit+Sca-1- hematopoietic stem cell in the E11.5 fetal liver is much lower than controls
• the frequency but not absolute number of Lin- c-Kit+Sca-1+ hematopoietic stem cell in the E11.5 fetal liver is much higher than controls
• similar differences in HSC frequencies are observed when AA4.1 is used as a marker instead of c-Kit

homeostasis/metabolism
increased circulating interferon-alpha level ( J:142338 )
• extracellular fluid from E11.5 embryos that have had their livers removed has 13-fold more interferon-alpha than controls
abnormal circulating interferon-beta level ( J:142338 )
• extracellular fluid from E11.5 embryos that have had their livers removed has 80-fold more interferon-beta than controls

immune system
increased circulating interferon-alpha level ( J:142338 )
• extracellular fluid from E11.5 embryos that have had their livers removed has 13-fold more interferon-alpha than controls
abnormal circulating interferon-beta level ( J:142338 )
• extracellular fluid from E11.5 embryos that have had their livers removed has 80-fold more interferon-beta than controls




Genotype
MGI:3029864
hm2
Allelic
Composition		 Adartm2Phs/Adartm2Phs
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adartm2Phs mutation (0 available); any Adar mutation (72 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

embryo
embryonic growth retardation ( J:87715 )
• slightly retarded development prior to death around E12

hematopoietic system
absent common myeloid progenitor cells ( J:87715 )
• reduced in the fetal liver
impaired hematopoiesis ( J:87715 )
• cell numbers in mutant embryonic hematopoietic tissues were significantly reduced in the yolk sac (to 52%), fetal liver (to 42%), and peripheral blood (to 63%) compared with control embryos

liver/biliary system
abnormal liver development ( J:87715 )
• disintegrating liver structure with reduced cell density evident at E11.5
• often blood accumulation in pathologically enlarged spaces
small liver ( J:87715 )
• significant size reduction of fetal liver evident at E12
• fetal liver size was normal until E11-E11.25

growth/size/body
embryonic growth retardation ( J:87715 )
• slightly retarded development prior to death around E12




Genotype
MGI:3029865
hm3
Allelic
Composition		 Adartm2Phs/Adartm2Phs
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * NMRI
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adartm2Phs mutation (0 available); any Adar mutation (72 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

embryo
embryonic growth retardation ( J:87715 )
• slightly retarded development prior to death around E12

hematopoietic system
absent common myeloid progenitor cells ( J:87715 )
• reduced in the fetal liver
impaired hematopoiesis ( J:87715 )
• cell numbers in mutant embryonic hematopoietic tissues were significantly reduced in the yolk sac (to 52%), fetal liver (to 42%), and peripheral blood (to 63%) compared with control embryos

liver/biliary system
abnormal liver development ( J:87715 )
• disintegrating liver structure with reduced cell density evident at E11.5
• often blood accumulation in pathologically enlarged spaces
small liver ( J:87715 )
• significant size reduction of fetal liver evident at E12
• fetal liver size was normal until E11-E11.25

growth/size/body
embryonic growth retardation ( J:87715 )
• slightly retarded development prior to death around E12




Genotype
MGI:3843982
cn4
Allelic
Composition		 Adartm1.1Phs/Adartm2Phs
Tg(Tal1-cre/ERT)42-056Jrg/?
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adartm1.1Phs mutation (2 available); any Adar mutation (72 available)
Adartm2Phs mutation (0 available); any Adar mutation (72 available)
Tg(Tal1-cre/ERT)42-056Jrg mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased bone marrow cell number ( J:142338 )
• bone marrow cellularity is reduced in mice after cre induction
abnormal hematopoietic stem cell morphology ( J:142338 )
• the frequency of Lin- c-Kit+Sca-1- hematopoietic stem cells (HSC) in the bone marrow after cre induction is much lower than controls
• the frequency of Lin- c-Kit+Sca-1+ HSC in the bone marrow after cre induction is much higher than controls
• 68% of actively cycling HSCs are apoptotic after cre induction versus 3-13% in control mice
• the bone marrow has many fewer Lin- c-Kit+Sca-1+CD34lo HSC cells




Genotype
MGI:3828311
cn5
Allelic
Composition		 Adartm1.1Phs/Adartm2Phs
Tg(Mx1-cre)1Cgn/?
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adartm1.1Phs mutation (2 available); any Adar mutation (72 available)
Adartm2Phs mutation (0 available); any Adar mutation (72 available)
Tg(Mx1-cre)1Cgn mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, complete penetrance ( J:142338 )
• mice die shortly after birth, even in the absence of cre induction by poly(I:C) administration

hematopoietic system
abnormal definitive hematopoiesis ( J:142338 )
• E14.5 fetal liver cells transplanted into wild-type hosts engraft normally but fail to replenish blood leukocytes after cre induction
• two weeks after cre induction, the contribution of the mutant cells to blood leukocytes is diminished by a fourth
• the contribution of these fetal liver cells to peripheral blood cells including myeloid, B-lymphoid and T-lymphoid lineages is negligible after 23 weeks of cre induction
• very few donor derived hematopoetic stem cells are found in the bone marrow after 23 weeks of cre induction

liver/biliary system
liver hypoplasia ( J:142338 )
• E14.5 embryos have slightly lower total liver cellularity even in the absence of cre induction by poly(I:C) administration




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11/12/2024
MGI 6.24 		The Jackson Laboratory