Phenotypes associated with this allele

• Allele Symbol: Adar^tm1.1Knk
• Allele Name: targeted mutation 1.1, Kazuko Nishikura
• Allele ID: MGI:3032487
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Adar^tm1.1Knk/Adar^tm1.1Knk	involves: 129S1/Sv * 129X1/SvJ	MGI:3032497
ht2	Adar^tm1.1Knk/Adar^+	involves: 129S1/Sv * 129X1/SvJ	MGI:5436589

Genotype
MGI:3032497

hm1

• Allelic Composition: Adar^tm1.1Knk/Adar^tm1.1Knk
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Widespread apoptosis in Adar^tm1.1Knk/Adar^tm1.1Knk embryos

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:87714 )

• death around E12

cardiovascular system

internal hemorrhage ( J:87714 )

• observed in the abdominal cavities of some embryos

cellular

increased sensitivity to induced cell death ( J:87714 )

• stress-induced apoptosis observed in MEFs

abnormal apoptosis ( J:87714 )

• highest levels of apoptosis during development are in the liver among both hepatocytes and hematopoietic cells

increased embryonic tissue cell apoptosis ( J:87714 )

• widespread apoptosis during development

increased hepatocyte apoptosis ( J:87714 )

embryo

increased embryonic tissue cell apoptosis ( J:87714 )

• widespread apoptosis during development

pale yolk sac ( J:87714 )

• observed in some embyros

hematopoietic system

hematopoietic system phenotype ( J:87714 )

N • normal numbers of definitive erythroid and myeloid progenitors in the E9.5 yolk sacs indicating normal primitive hematopoiesis

N • embryonic death precluded the observation of definitive erythropoiesis

liver/biliary system

increased hepatocyte apoptosis ( J:87714 )

Genotype
MGI:5436589

ht2

• Allelic Composition: Adar^tm1.1Knk/Adar⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

mortality/aging

mortality/aging ( J:87714 )

N • unexpectedly, mice survived normally