Phenotypes associated with this allele

• Allele Symbol: Syn1^tm1Noh
• Allele Name: targeted mutation 1, Nobutaka Hirokawa
• Allele ID: MGI:3032534
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Syn1^tm1Noh/Syn1^tm1Noh	involves: 129S4/SvJae	MGI:3719398
hm2	Syn1^tm1Noh/Syn1^tm1Noh	involves: 129S4/SvJae * C57BL/6	MGI:3719351

Genotype
MGI:3719398

hm1

• Allelic Composition: Syn1^tm1Noh/Syn1^tm1Noh
• Genetic Background: involves: 129S4/SvJae

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal CNS synapse formation ( J:30400 )

♀ • hippocampal and cerebellar synapse size is reduced

♀ • axons are smooth and lack varicosity-like expansions seen in wild-type axons

abnormal synaptic vesicle clustering ( J:30400 )

♀ • synaptic vesicle density is reduced in hippocampal and cerebellar synapses

♀ • cross-bridges between synaptic vesicles are observed in cerebellar mossy fiber terminals

Genotype
MGI:3719351

hm2

• Allelic Composition: Syn1^tm1Noh/Syn1^tm1Noh
• Genetic Background: involves: 129S4/SvJae * C57BL/6

nervous system

abnormal synaptic vesicle clustering ( J:55506 )

♀ • vesicles fail to accumulate at inhibitory preterminals after repeated exposure to a hypertonic solution

abnormal synaptic vesicle recycling ( J:55506 )

♀ • vesicle replenishing at inhibitory synapses is accelerated compared to in wild-type mice

abnormal inhibitory postsynaptic currents ( J:55506 )

♀ • after a 5 minute interval and a second application of hypertonic solution caused, a smaller increase in miniature inhibitory postsynaptic currents (IPSCs) is observed and fewer quanta are released than in wild-type mice in inhibitory synapses

♀ • IPSCs in CA3 pyramidal cells have wider scatter than in wild-type mice