Phenotypes associated with this allele

• Allele Symbol: Syn1^tm2Noh
• Allele Name: targeted mutation 2, Nobutaka Hirokawa
• Allele ID: MGI:3032535
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Syn1^tm2Noh/Syn1^tm2Noh	involves: 129S4/SvJae	MGI:3719399

Genotype
MGI:3719399

hm1

• Allelic Composition: Syn1^tm2Noh/Syn1^tm2Noh
• Genetic Background: involves: 129S4/SvJae

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal CNS synapse formation ( J:30400 )

♀ • hippocampal and cerebellar synapse size is reduced

♀ • axons are smooth and lack varicosity-like expansions seen in wild-type axons

abnormal synaptic vesicle clustering ( J:30400 )

♀ • synaptic vesicle density is reduced in hippocampal and cerebellar synapses

♀ • cross-bridges between synaptic vesicles are observed in cerebellar mossy fiber terminals