Phenotypes associated with this allele

• Allele Symbol: Trp53^tm2Glo
• Allele Name: targeted mutation 2, Guillermina Lozano
• Allele ID: MGI:3032598
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Trp53^tm2Glo/Trp53^tm2Glo	involves: 129/Sv * C57BL/6	MGI:3032609
cx2	Mdm2^tm1Glo/Mdm2^tm1Glo Trp53^tm2Glo/Trp53^tm2Glo	involves: 129S7/SvEvBrd	MGI:5140400

Genotype
MGI:3032609

hm1

• Allelic Composition: Trp53^tm2Glo/Trp53^tm2Glo
• Genetic Background: involves: 129/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased tumor-free survival time ( J:87501 )

• 15% had died by 7 months of age, with the remaining 85% being tumor-free

neoplasm

increased tumor incidence ( J:87501 )

• mice developed lymphomas and sarcomas between 7 and 13 months of age

• delayed onset relative to Trp53 null mice

• no pronounced aneuploidy in tumor cells

increased lymphoma incidence ( J:87501 )

• exhibited by 43% of mice

• most lymphomas were in the spleen and lymph nodes

increased sarcoma incidence ( J:87501 )

cellular

abnormal apoptosis ( J:87501 )

• Trp53-dependent apoptosis was not observed in response to DNA damage or oncogenic signaling

Genotype
MGI:5140400

cx2

• Allelic Composition: Mdm2^tm1Glo/Mdm2^tm1Glo; Trp53^tm2Glo/Trp53^tm2Glo
• Genetic Background: involves: 129S7/SvEvBrd

hematopoietic system

anemia ( J:174216 )

• bone marrow sections show hypocellularity indicative of aplastic anemia

decreased bone marrow cell number ( J:174216 )

• bone marrow sections show hypocellularity indicative of aplastic anemia

nervous system

abnormal Purkinje cell morphology ( J:174216 )

• distribution of Purkinje neurons is disorganized in the cerebellum

decreased cerebellar granule cell number ( J:174216 )

small cerebellum ( J:174216 )