Phenotypes associated with this allele

• Allele Symbol: Actb^{tm1(PyVT)Arge}
• Allele Name: targeted mutation 1, Argiris Efstratiadis
• Allele ID: MGI:3032612
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Actb^tm1(PyVT)Arge/Actb^+	involves: 129S1/Sv	MGI:3032630
cn2	Actb^tm1(PyVT)Arge/Actb^+ Wap^tm1(cre)Arge/Wap^+	involves: 129S1/Sv	MGI:3032632
cn3	Actb^tm1(PyVT)Arge/Actb^+ Tg(Hsp70-1-cre)1Arge/0	involves: 129S1/Sv * C57BL/6J * CBA	MGI:3032631

Genotype
MGI:3032630

ht1

• Allelic Composition: Actb^{tm1(PyVT)Arge}/Actb⁺
• Genetic Background: involves: 129S1/Sv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:87544 )

neoplasm

increased mammary adenocarcinoma incidence ( J:87544 )

• some post-partum females developed tumors as a result of cre-independent excision of the floxed neo cassette

• lung metastases were observed in some cases

increased hemangioma incidence ( J:87544 )

• associated with cre-independent excision of the floxed neomycin cassette

integument

increased mammary adenocarcinoma incidence ( J:87544 )

• some post-partum females developed tumors as a result of cre-independent excision of the floxed neo cassette

• lung metastases were observed in some cases

endocrine/exocrine glands

increased mammary adenocarcinoma incidence ( J:87544 )

• some post-partum females developed tumors as a result of cre-independent excision of the floxed neo cassette

• lung metastases were observed in some cases

Genotype
MGI:3032632

cn2

• Allelic Composition: Actb^{tm1(PyVT)Arge}/Actb⁺; Wap^tm1(cre)Arge/Wap⁺
• Genetic Background: involves: 129S1/Sv

mortality/aging

premature death ( J:87544 )

• premature death

neoplasm

increased mammary adenocarcinoma incidence ( J:87544 )

cardiovascular system

decreased cardiac muscle contractility ( J:87544 )

• exhibited by 70% of females (mostly virgins, indicating that this phenotype is associated with cre-independent excision of the floxed neomycin cassette)

muscle

decreased cardiac muscle contractility ( J:87544 )

• exhibited by 70% of females (mostly virgins, indicating that this phenotype is associated with cre-independent excision of the floxed neomycin cassette)

integument

increased mammary adenocarcinoma incidence ( J:87544 )

endocrine/exocrine glands

increased mammary adenocarcinoma incidence ( J:87544 )

Genotype
MGI:3032631

cn3

• Allelic Composition: Actb^{tm1(PyVT)Arge}/Actb⁺; Tg(Hsp70-1-cre)1Arge/0
• Genetic Background: involves: 129S1/Sv * C57BL/6J * CBA

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:87544 )

• death by E6.5