Phenotypes associated with this allele

• Allele Symbol: Actb^tm2(Tag)Arge
• Allele Name: targeted mutation 2, Argiris Efstratiadis
• Allele ID: MGI:3032619
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Actb^tm2(Tag)Arge/Actb^+	involves: 129S1/Sv	MGI:3032633
cn2	Actb^tm2(Tag)Arge/Actb^+ Tg(Hsp70-1-cre)1Arge/0	involves: 129S1/Sv * C57BL/6J * CBA	MGI:3032629

Genotype
MGI:3032633

ht1

• Allelic Composition: Actb^tm2(Tag)Arge/Actb⁺
• Genetic Background: involves: 129S1/Sv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased sarcoma incidence ( J:87544 )

• some females developed tumors as a result of cre-independent excision of the floxed neo cassette

Genotype
MGI:3032629

cn2

• Allelic Composition: Actb^tm2(Tag)Arge/Actb⁺; Tg(Hsp70-1-cre)1Arge/0
• Genetic Background: involves: 129S1/Sv * C57BL/6J * CBA

neoplasm

increased leiomyosarcoma incidence ( J:87544 )

• females exhibited uterine leiomyosacromas around 3 months of age

endocrine/exocrine glands

enlarged seminal vesicle ( J:87544 )

♂ • enlarged due to pronounced hyperplasia of smooth muscle layers

enlarged gallbladder ( J:87544 )

• marked dilation in both males and females due to smooth muscle proliferation

liver/biliary system

enlarged gallbladder ( J:87544 )

• marked dilation in both males and females due to smooth muscle proliferation

muscle

abnormal smooth muscle morphology ( J:87544 )

• smooth muscle hyperproliferation in both males and females

increased leiomyosarcoma incidence ( J:87544 )

• females exhibited uterine leiomyosacromas around 3 months of age

reproductive system

enlarged seminal vesicle ( J:87544 )

♂ • enlarged due to pronounced hyperplasia of smooth muscle layers

abnormal uterus morphology ( J:87544 )

♀ • development of leiomyosarcomas in the uterus

growth/size/body

enlarged gallbladder ( J:87544 )

• marked dilation in both males and females due to smooth muscle proliferation