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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gli2tm5(GLI3)Alj
targeted mutation 5, Alexandra L Joyner
MGI:3032718
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Gli2tm5(GLI3)Alj/Gli2tm5(GLI3)Alj involves: Swiss Webster MGI:3032762
ht2
 		Gli2tm5(GLI3)Alj/Gli2tm1Alj involves: 129S1/Sv * 129X1/SvJ * Swiss Webster MGI:4414941


Genotype
MGI:3032762
hm1
Allelic
Composition		 Gli2tm5(GLI3)Alj/Gli2tm5(GLI3)Alj
Genetic
Background		 involves: Swiss Webster
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli2tm5(GLI3)Alj mutation (0 available); any Gli2 mutation (169 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal floor plate morphology ( J:87948 )
• some floor plate cells form in the cervical and forelimb regions but not in the trunk and hindlimb regions
abnormal neuron specification ( J:87948 )
• abnormal spatial patterning of ventral spinal cord progenitors
• partial rescue (less than Gli2tm5.1(GLI3)Alj homozygotes) of the spinal cord development phenotype observed in Gli2tm1Alj homozygotes
abnormal ventral interneuron 3 morphology ( J:87948 )
• partial rescue of V3 interneuron generation

embryo
abnormal floor plate morphology ( J:87948 )
• some floor plate cells form in the cervical and forelimb regions but not in the trunk and hindlimb regions




Genotype
MGI:4414941
ht2
Allelic
Composition		 Gli2tm5(GLI3)Alj/Gli2tm1Alj
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * Swiss Webster
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli2tm1Alj mutation (0 available); any Gli2 mutation (169 available)
Gli2tm5(GLI3)Alj mutation (0 available); any Gli2 mutation (169 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
abnormal neural tube morphology ( J:87948 )
• phenotype is similar to that of Gli2tm1Alj mutant embryos, indicating that a low level of Gli3 is not enough to substitute for Gli2
absent floor plate ( J:87948 )
• absence of floor plate cells throughout the anterior/posterior (A/P) axis of the spinal cord

nervous system
abnormal neural tube morphology ( J:87948 )
• phenotype is similar to that of Gli2tm1Alj mutant embryos, indicating that a low level of Gli3 is not enough to substitute for Gli2
absent floor plate ( J:87948 )
• absence of floor plate cells throughout the anterior/posterior (A/P) axis of the spinal cord




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/22/2024
MGI 6.24 		The Jackson Laboratory