Phenotypes associated with this allele

• Allele Symbol: Gli2^tm5(GLI3)Alj
• Allele Name: targeted mutation 5, Alexandra L Joyner
• Allele ID: MGI:3032718
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gli2^tm5(GLI3)Alj/Gli2^tm5(GLI3)Alj	involves: Swiss Webster	MGI:3032762
ht2	Gli2^tm5(GLI3)Alj/Gli2^tm1Alj	involves: 129S1/Sv * 129X1/SvJ * Swiss Webster	MGI:4414941

Genotype
MGI:3032762

hm1

• Allelic Composition: Gli2^tm5(GLI3)Alj/Gli2^tm5(GLI3)Alj
• Genetic Background: involves: Swiss Webster

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal floor plate morphology ( J:87948 )

• some floor plate cells form in the cervical and forelimb regions but not in the trunk and hindlimb regions

abnormal neuron specification ( J:87948 )

• abnormal spatial patterning of ventral spinal cord progenitors

• partial rescue (less than Gli2^{tm5.1(GLI3)Alj} homozygotes) of the spinal cord development phenotype observed in Gli2^tm1Alj homozygotes

abnormal ventral interneuron 3 morphology ( J:87948 )

• partial rescue of V3 interneuron generation

embryo

abnormal floor plate morphology ( J:87948 )

• some floor plate cells form in the cervical and forelimb regions but not in the trunk and hindlimb regions

Genotype
MGI:4414941

ht2

• Allelic Composition: Gli2^tm5(GLI3)Alj/Gli2^tm1Alj
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Swiss Webster

embryo

abnormal neural tube morphology ( J:87948 )

• phenotype is similar to that of Gli2^tm1Alj mutant embryos, indicating that a low level of Gli3 is not enough to substitute for Gli2

absent floor plate ( J:87948 )

• absence of floor plate cells throughout the anterior/posterior (A/P) axis of the spinal cord

nervous system

abnormal neural tube morphology ( J:87948 )

• phenotype is similar to that of Gli2^tm1Alj mutant embryos, indicating that a low level of Gli3 is not enough to substitute for Gli2

absent floor plate ( J:87948 )

• absence of floor plate cells throughout the anterior/posterior (A/P) axis of the spinal cord