Analysis Tools|
Allele Symbol Allele Name Allele ID |
Gli2tm5.1(GLI3)Alj targeted mutation 5.1, Alexandra L Joyner MGI:3032719 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• pups live for only 2 days after birth
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• abnormal spatial patterning of ventral spinal cord progenitors
• partial rescue of the spinal cord development phenotype observed in homozygous Gli2tm1Alj mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• absence of floor plate cells throughout the anterior/posterior (A/P) axis of the spinal cord
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• decrease in number of V3 interneurons that occupy the ventral midline
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• absence of floor plate cells throughout the anterior/posterior (A/P) axis of the spinal cord
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| N |
• almost complete rescue of the pre-axial limb polydactyly observed in Gli3 mutants
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• absence of floor plate cells throughout the anterior/posterior (A/P) axis of the spinal cord
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• only a very small number of V3 interneurons are seen in the ventral midline of the spinal cord
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• absence of floor plate cells throughout the anterior/posterior (A/P) axis of the spinal cord
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 10/22/2024 MGI 6.24 |
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