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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gsta4tm1Pzim
targeted mutation 1, Piotr Zimniak
MGI:3032766
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Gsta4tm1Pzim/Gsta4tm1Pzim involves: 129S1/Sv * 129S6/SvEvTac MGI:3032767
ht2
 		Gsta4tm1Pzim/Gsta4+ involves: 129S1/Sv * 129S6/SvEvTac MGI:3032836


Genotype
MGI:3032767
hm1
Allelic
Composition		 Gsta4tm1Pzim/Gsta4tm1Pzim
Genetic
Background		 involves: 129S1/Sv * 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gsta4tm1Pzim mutation (0 available); any Gsta4 mutation (65 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
oxidative stress ( J:87983 )
• increased sensitivity to oxidative stress, demonstrated by decreased survival after chronic intraperitoneal administration of paraquat

homeostasis/metabolism
increased circulating alanine transaminase level ( J:87983 )
• possibly indicative of liver damage
increased circulating aspartate transaminase level ( J:87983 )
• possibly indicative of liver damage
abnormal metabolism ( J:87983 )
• reduced ability to conjugate 4-hydroxynon-2-enal (4-HNE), resulting in the accumulation of 4-HNE in various tissues

immune system
abnormal bone marrow development ( J:87983 )
• increased bone marrow fat content, putatively due to altered adipocyte differentiation or function
• normal bone density, therefore decreased bone to fat ratio
increased susceptibility to bacterial infection ( J:87983 )
• observation of bacterial infections that arose in the breeding colony showed a statistically significant increase in the incidence of Staphylococcus aureus infection relative to heterozygous and wild-type mice

reproductive system




Genotype
MGI:3032836
ht2
Allelic
Composition		 Gsta4tm1Pzim/Gsta4+
Genetic
Background		 involves: 129S1/Sv * 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gsta4tm1Pzim mutation (0 available); any Gsta4 mutation (65 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased susceptibility to bacterial infection ( J:87983 )
• observation of bacterial infections that arose in the breeding colony showed a statistically significant increase in the incidence of Staphylococcus aureus infection relative to wild-type mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory