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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Lck*F505)2964Rmp
transgene insertion 2964, Roger M Perlmutter
MGI:3032774
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Ptprctm1Holm/Ptprctm1Holm
Tg(Lck*F505)2964Rmp/? 		involves: 129/Sv * C57BL/6 * DBA/2 MGI:3032909
tg2
 		Tg(Lck*F505)2964Rmp/? involves: C57BL/6J * DBA/2 MGI:3032812


Genotype
MGI:3032909
cx1
Allelic
Composition		 Ptprctm1Holm/Ptprctm1Holm
Tg(Lck*F505)2964Rmp/?
Genetic
Background		 involves: 129/Sv * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptprctm1Holm mutation (11 available); any Ptprc mutation (189 available)
Tg(Lck*F505)2964Rmp mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased T cell derived lymphoma incidence ( J:64671 )
• aggressive thymic tumors in 100% of mice
• extensive metastasis
• earliest morbidity at 5 weeks and median survival was to 9.5 weeks
• thymomas originate from immature thymocytes

immune system
thymus hyperplasia ( J:64671 )
• thymus glands with tumours also have 5X normal cell numbers
increased T cell derived lymphoma incidence ( J:64671 )
• aggressive thymic tumors in 100% of mice
• extensive metastasis
• earliest morbidity at 5 weeks and median survival was to 9.5 weeks
• thymomas originate from immature thymocytes

hematopoietic system
thymus hyperplasia ( J:64671 )
• thymus glands with tumours also have 5X normal cell numbers
increased T cell derived lymphoma incidence ( J:64671 )
• aggressive thymic tumors in 100% of mice
• extensive metastasis
• earliest morbidity at 5 weeks and median survival was to 9.5 weeks
• thymomas originate from immature thymocytes

endocrine/exocrine glands
thymus hyperplasia ( J:64671 )
• thymus glands with tumours also have 5X normal cell numbers
increased T cell derived lymphoma incidence ( J:64671 )
• aggressive thymic tumors in 100% of mice
• extensive metastasis
• earliest morbidity at 5 weeks and median survival was to 9.5 weeks
• thymomas originate from immature thymocytes




Genotype
MGI:3032812
tg2
Allelic
Composition		 Tg(Lck*F505)2964Rmp/?
Genetic
Background		 involves: C57BL/6J * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
neoplasm ( J:88309 )
N
• unlike mice carrying transgenes of this gene which express greater than 20 pg of mRNA per ug of total RNA, no thymic tumors develop during the first year of life




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory