Phenotypes associated with this allele

• Allele Symbol: Sgk3^fz-ica
• Allele Name: iasi congenital atrichia
• Allele ID: MGI:3032837
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sgk3^fz-ica/Sgk3^fz-ica	Swiss albino	MGI:3032932

Genotype
MGI:3032932

hm1

• Allelic Composition: Sgk3^fz-ica/Sgk3^fz-ica
• Genetic Background: Swiss albino

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal inflammatory response ( J:107373 )

• inflammatory cell infiltrates observed around hair shafts lying within the dermal mescenchyme

integument

alopecia ( J:88408 , J:107373 )

• from the front region, by age of 20-30 days, the weak, underdeveloped sparse hairs are lost the pups remain completely lacking of hairs (J:88408)

• during the following 4-5 months, another 2-3 growth waves of sparse fuzzy hairs occur; then the adults remain without a coat with the exception of a perinasal tuft and some short hairs at the tail base (J:88408)

sparse hair ( J:88408 , J:107373 )

• starting at the day 6 until 10-12 days of age, homozygous pups have on their body sparse, short, thin, and fuzzy hairs (J:88408)

abnormal hair shaft morphology ( J:107373 )

• shaft consists of cuticle and cortex only

• shaft lacks trichohyalin granules

abnormal hair cuticle ( J:107373 )

• Huxley layer contains multiple large intracytoplasmic vacuoles, evidence of cell fragmentation, and trychohyalin granules of variable and irregular size

abnormal hair medulla ( J:107373 )

• hair shafts lack a distinctive medulla by day 8

thin hair shaft ( J:107373 )

• hair shafts are thin and few penetrate the skin by day 8

abnormal hair follicle morphology ( J:107373 )

• follicles exhibit a curved shape with thin hypodermal connective tissue

abnormal hair follicle development ( J:107373 )

• by day 5, stage 8 follicles exhibit a curved shape and few hair shafts are found within the follicular infundibulum

• premature catagen induction, shortened telogen, and early anagen development observed by day 12

small hair follicles ( J:107373 )

• follicles are smaller than wildtype

curly vibrissae ( J:88408 , J:107373 )

• homozygotes have curly vibrissae throughout their lives (J:88408)

abnormal hair cycle ( J:107373 )

• acceleration of cycle

abnormal hair cycle telogen phase ( J:107373 )

• telogen phase shortened

accelerated hair follicle regression ( J:107373 )

• catagen observed by day 12; characterized by keratinocyte apoptosis

thick epidermis ( J:107373 )

• despite thickening, epidermal keratinization process is normal