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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Ightm1Tim
targeted mutation 1, Tim Manser
MGI:3032982
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Igh-Jtm1Dhu/Ightm1Tim involves: 129X1/SvJ * C57BL/6 MGI:3033131


Genotype
MGI:3033131
cx1
Allelic
Composition
Igh-Jtm1Dhu/Ightm1Tim
Genetic
Background
involves: 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igh-Jtm1Dhu mutation (1 available); any Igh-J mutation (13 available)
Ightm1Tim mutation (0 available); any Igh mutation (44 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• cell surface IgM levels are generally lower and particularly lower in E4+ cells
• cell surface IgD levels are normal except in E4+ cells where it is dramatically reduced
• lambda-L chain levels were elevated 3X generally but were undetectable in E4+ B cells
• B cell development was normal in bone marrow
• splenic B cells with a follicular phenotype and are E4+
• B cells do not express endogenous mu-chain
• B cell area decreased in size

immune system
• cell surface IgM levels are generally lower and particularly lower in E4+ cells
• cell surface IgD levels are normal except in E4+ cells where it is dramatically reduced
• lambda-L chain levels were elevated 3X generally but were undetectable in E4+ B cells
• B cell development was normal in bone marrow
• splenic B cells with a follicular phenotype and are E4+
• B cells do not express endogenous mu-chain
• B cell area decreased in size





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last database update
11/19/2024
MGI 6.24
The Jackson Laboratory