hematopoietic system
• cell surface IgM levels are generally lower and particularly lower in E4+ cells
• cell surface IgD levels are normal except in E4+ cells where it is dramatically reduced
• lambda-L chain levels were elevated 3X generally but were undetectable in E4+ B cells
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• B cell development was normal in bone marrow
• splenic B cells with a follicular phenotype and are E4+
• B cells do not express endogenous mu-chain
|
• B cell area decreased in size
|
immune system
• cell surface IgM levels are generally lower and particularly lower in E4+ cells
• cell surface IgD levels are normal except in E4+ cells where it is dramatically reduced
• lambda-L chain levels were elevated 3X generally but were undetectable in E4+ B cells
|
• B cell development was normal in bone marrow
• splenic B cells with a follicular phenotype and are E4+
• B cells do not express endogenous mu-chain
|
• B cell area decreased in size
|