All Phenotypes Igh<tm2Tim> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Igh^tm2Tim
targeted mutation 2, Tim Manser
MGI:3032983

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Igh-J^tm1Dhu/Igh^tm2Tim	involves: 129X1/SvJ * C57BL/6	MGI:3033132

Allelic Composition	Igh-J^tm1Dhu/Igh^tm2Tim
Genetic Background	involves: 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igh-J^tm1Dhu mutation (1 available); any Igh-J mutation (13 available)
Igh^tm2Tim mutation (0 available); any Igh mutation (44 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal spleen morphology ( J:87624 )

• cell surface IgM levels are somewhat lower in B220+ and E4+ cells

• two cell populations, one in which surface IgD levels are normal, another in which they are substantially reduced

decreased marginal zone B cell number ( J:87624 )

• modestly reduced

immune system

abnormal spleen morphology ( J:87624 )

• cell surface IgM levels are somewhat lower in B220+ and E4+ cells

• two cell populations, one in which surface IgD levels are normal, another in which they are substantially reduced

decreased marginal zone B cell number ( J:87624 )

• modestly reduced

abnormal lymph node morphology ( J:87624 )

• cell surface IgD levels as in the spleen

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