Phenotypes associated with this allele

• Allele Symbol: Gck^Rgsc210
• Allele Name: RIKEN Genomic Sciences Center (GSC), 210
• Allele ID: MGI:3033222
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gck^Rgsc210/Gck^Rgsc210	involves: C57BL/6J * DBA/2J	MGI:3038213
ht2	Gck^Rgsc210/Gck^+	involves: C57BL/6J * DBA/2J	MGI:3038212

Genotype
MGI:3038213

hm1

• Allelic Composition: Gck^Rgsc210/Gck^Rgsc210
• Genetic Background: involves: C57BL/6J * DBA/2J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality ( J:88919 )

• homozygotes die within 1 week of birth

growth/size/body

decreased body weight ( J:88919 )

• by P2 homozygotes are obviously growth retarded

homeostasis/metabolism

hyperglycemia ( J:88919 )

• hyperglycemia is apparent by P2

• blood glucose levels exceed 600 mg/dl by P4

decreased liver glycogen level ( J:88919 )

• histological analysis reveals reduced liver glycogen levels

increased urine glucose level ( J:88919 )

• at P1-2 marked glucosuria is seen

liver/biliary system

decreased liver glycogen level ( J:88919 )

• histological analysis reveals reduced liver glycogen levels

hepatic steatosis ( J:88919 )

• the liver is markedly steatotic by P4

• histological analysis reveals enlarged fat droplets in hepatocytes

renal/urinary system

increased urine glucose level ( J:88919 )

• at P1-2 marked glucosuria is seen

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
maturity-onset diabetes of the young type 2		DOID:0111100	OMIM:125851	J:88919

Genotype
MGI:3038212

ht2

• Allelic Composition: Gck^Rgsc210/Gck⁺
• Genetic Background: involves: C57BL/6J * DBA/2J

homeostasis/metabolism

increased glycosylated hemoglobin level ( J:88919 )

• increased glycosylated hemoglobin indicating a prolonged increase in serum glucose

hyperglycemia ( J:88919 )

• mutants have a free fed serum glucose level of 200 mg/dl or more, this was the basis for selection in the ENU screen

impaired glucose tolerance ( J:88919 )

• during an oral glucose tolerance test blood glucose levels are significantly higher

hematopoietic system

increased glycosylated hemoglobin level ( J:88919 )

• increased glycosylated hemoglobin indicating a prolonged increase in serum glucose

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
maturity-onset diabetes of the young type 2		DOID:0111100	OMIM:125851	J:88919