Phenotypes associated with this allele

• Allele Symbol: Gck^Rgsc392
• Allele Name: RIKEN Genomic Sciences Center (GSC), 392
• Allele ID: MGI:3033225
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gck^Rgsc392/Gck^Rgsc392	involves: C57BL/6J * DBA/2J	MGI:3038219
ht2	Gck^Rgsc392/Gck^+	involves: C57BL/6J * DBA/2J	MGI:3038218

Genotype
MGI:3038219

hm1

• Allelic Composition: Gck^Rgsc392/Gck^Rgsc392
• Genetic Background: involves: C57BL/6J * DBA/2J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body weight ( J:88919 )

• growth retardation is not as severe as in Gck^1Rgsc and Gck^6Rgsc

homeostasis/metabolism

hyperglycemia ( J:88919 )

• hyperglycemia is detected by P2

• blood glucose levels reach 500 mg/dl and remain this high for at least 3 weeks after birth

decreased liver glycogen level ( J:88919 )

• histological analysis reveals reduced liver glycogen levels

liver/biliary system

decreased liver glycogen level ( J:88919 )

• histological analysis reveals reduced liver glycogen levels

hepatic steatosis ( J:88919 )

• histological analysis reveals increased numbers of fat droplets in hepatocytes however the gross appearance on the liver does not differ from wild-type

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
maturity-onset diabetes of the young type 2		DOID:0111100	OMIM:125851	J:88919

Genotype
MGI:3038218

ht2

• Allelic Composition: Gck^Rgsc392/Gck⁺
• Genetic Background: involves: C57BL/6J * DBA/2J

homeostasis/metabolism

increased glycosylated hemoglobin level ( J:88919 )

• increased glycosylated hemoglobin indicating a prolonged increase in serum glucose

hyperglycemia ( J:88919 )

• mutants have a free fed serum glucose level of 200 mg/dl or more, this was the basis for selection in the ENU screen

decreased circulating insulin level ( J:88919 )

• mutants have impaired glucose responsive insulin secretion

impaired glucose tolerance ( J:88919 )

• during an oral glucose tolerance test blood glucose levels are significantly higher

hematopoietic system

increased glycosylated hemoglobin level ( J:88919 )

• increased glycosylated hemoglobin indicating a prolonged increase in serum glucose

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
maturity-onset diabetes of the young type 2		DOID:0111100	OMIM:125851	J:88919