Phenotypes associated with this allele

• Allele Symbol: Gck^Rgsc149
• Allele Name: RIKEN Genomic Sciences Center (GSC), 149
• Allele ID: MGI:3033228
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Gck^Rgsc149/Gck^+	involves: C57BL/6J * DBA/2J	MGI:3590142
ht2	Gck^Rgsc149/Gck^+	involves: C57BL/6JJcl * DBA/2JJcl	MGI:3798893

Genotype
MGI:3590142

ht1

• Allelic Composition: Gck^Rgsc149/Gck⁺
• Genetic Background: involves: C57BL/6J * DBA/2J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased glycosylated hemoglobin level ( J:88919 )

• increased glycosylated hemoglobin indicating a prolonged increase in serum glucose

hyperglycemia ( J:88919 )

• mutants have a free fed serum glucose level of 200 mg/dl or more, this was the basis for selection in the ENU screen

hematopoietic system

increased glycosylated hemoglobin level ( J:88919 )

• increased glycosylated hemoglobin indicating a prolonged increase in serum glucose

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
maturity-onset diabetes of the young type 2		DOID:0111100	OMIM:125851	J:88919

Genotype
MGI:3798893

ht2

• Allelic Composition: Gck^Rgsc149/Gck⁺
• Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl

homeostasis/metabolism

hyperglycemia ( J:133634 )

• blood glucose of 11 week-old mice heterozygous for this mutation is elevated (289 mg/dL vs. a control range of 73.1-182.7 mg/dL)