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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(S100b-v-erbB)4496Waw
transgene insertion 4496, William A Weiss
MGI:3033302
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Tg(S100b-v-erbB)4496Waw/0
Trp53tm1Brd/Trp53tm1Brd 		involves: 129S7/SvEvBrd * C57BL/6J * DBA/2J MGI:5762620
cx2
 		Rb1tm1Tyj/Rb1+
Tg(S100b-v-erbB)4496Waw/0 		involves: 129S2/SvPas * C57BL/6J * DBA/2J * FVB/N MGI:3822322
cx3
 		Tg(S100b-v-erbB)4496Waw/0
Trp53tm1Brd/Trp53+ 		involves: 129S7/SvEvBrd * C57BL/6J * DBA/2J * FVB/N MGI:3822323
cx4
 		Cdkn2atm1Rdp/Cdkn2atm1Rdp
Tg(S100b-v-erbB)4496Waw/0 		involves: 129/Sv * C57BL/6J * DBA/2J * FVB/N * SJL MGI:3822320
cx5
 		Cdkn2atm1Rdp/Cdkn2a+
Tg(S100b-v-erbB)4496Waw/0 		involves: 129/Sv * C57BL/6J * DBA/2J * FVB/N * SJL MGI:3822321
tg6
 		Tg(S100b-v-erbB)4496Waw/0 involves: C57BL/6J * DBA/2J * FVB/N MGI:3822319


Genotype
MGI:5762620
cn1
Allelic
Composition		 Tg(S100b-v-erbB)4496Waw/0
Trp53tm1Brd/Trp53tm1Brd
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6J * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(S100b-v-erbB)4496Waw mutation (1 available)
Trp53tm1Brd mutation (5 available); any Trp53 mutation (240 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased glioma incidence ( J:225862 )
• marker analysis indicates that oligodendroglial progenitor cell-derived high grade glioma has proneural character
• in vivo radiation of the high grade glioma induces proneural-to-mesenchymal transition, increasing invasiveness and malignancy
• irradiated proneural high grade glioma cells undergoing proneural-to-mesenchymal transition show increased invasiveness and resistance to temozolomide treatment

nervous system
increased glioma incidence ( J:225862 )
• marker analysis indicates that oligodendroglial progenitor cell-derived high grade glioma has proneural character
• in vivo radiation of the high grade glioma induces proneural-to-mesenchymal transition, increasing invasiveness and malignancy
• irradiated proneural high grade glioma cells undergoing proneural-to-mesenchymal transition show increased invasiveness and resistance to temozolomide treatment

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
high grade glioma DOID:3070 OMIM:PS137800
 J:137800




Genotype
MGI:3822322
cx2
Allelic
Composition		 Rb1tm1Tyj/Rb1+
Tg(S100b-v-erbB)4496Waw/0
Genetic
Background		 involves: 129S2/SvPas * C57BL/6J * DBA/2J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rb1tm1Tyj mutation (5 available); any Rb1 mutation (111 available)
Tg(S100b-v-erbB)4496Waw mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased glioma incidence ( J:82649 )
• mice develop gliomas in the same pattern and with the same pathology as in Tg(S100b-v-erbB)4496Waw mice

nervous system
increased glioma incidence ( J:82649 )
• mice develop gliomas in the same pattern and with the same pathology as in Tg(S100b-v-erbB)4496Waw mice




Genotype
MGI:3822323
cx3
Allelic
Composition		 Tg(S100b-v-erbB)4496Waw/0
Trp53tm1Brd/Trp53+
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6J * DBA/2J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(S100b-v-erbB)4496Waw mutation (1 available)
Trp53tm1Brd mutation (5 available); any Trp53 mutation (240 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:82649 )
• 80% of mice die within 6 months of high grade oligodendroglioma

neoplasm
increased glioma incidence ( J:82649 )
• mice develop gliomas as in Cdkn2atm1Rdp/Cdkn2atm1Rdp Tg(S100b-v-erbB)4496Waw mice with loss of function of the wild-type Trp53 allele
increased oligodendroglioma incidence ( J:82649 )
• 80% of mice die within 6 months of high grade oligodendroglioma

nervous system
increased glioma incidence ( J:82649 )
• mice develop gliomas as in Cdkn2atm1Rdp/Cdkn2atm1Rdp Tg(S100b-v-erbB)4496Waw mice with loss of function of the wild-type Trp53 allele
increased oligodendroglioma incidence ( J:82649 )
• 80% of mice die within 6 months of high grade oligodendroglioma

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
oligodendroglioma DOID:3181 J:82649




Genotype
MGI:3822320
cx4
Allelic
Composition		 Cdkn2atm1Rdp/Cdkn2atm1Rdp
Tg(S100b-v-erbB)4496Waw/0
Genetic
Background		 involves: 129/Sv * C57BL/6J * DBA/2J * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2atm1Rdp mutation (6 available); any Cdkn2a mutation (67 available)
Tg(S100b-v-erbB)4496Waw mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:82649 )
• 75% of mice die by 2 months of age and 90% of mice are dead by 6 months due to development of oligodendroglioma

neoplasm
increased glioma incidence ( J:82649 )
• mice exhibit increased penetrance of glioma development compared to Tg(S100b-v-erbB)4496Waw mice
increased oligodendroglioma incidence ( J:82649 )
• 75% of mice die by 2 months of age and 90% of mice are dead by 6 months due to development of oligodendroglioma
decreased tumor latency ( J:82649 )
• mice exhibit decreased latency of glioma development compared to Tg(S100b-v-erbB)4496Waw mice

nervous system
increased glioma incidence ( J:82649 )
• mice exhibit increased penetrance of glioma development compared to Tg(S100b-v-erbB)4496Waw mice
increased oligodendroglioma incidence ( J:82649 )
• 75% of mice die by 2 months of age and 90% of mice are dead by 6 months due to development of oligodendroglioma

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
oligodendroglioma DOID:3181 J:82649




Genotype
MGI:3822321
cx5
Allelic
Composition		 Cdkn2atm1Rdp/Cdkn2a+
Tg(S100b-v-erbB)4496Waw/0
Genetic
Background		 involves: 129/Sv * C57BL/6J * DBA/2J * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2atm1Rdp mutation (6 available); any Cdkn2a mutation (67 available)
Tg(S100b-v-erbB)4496Waw mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased glioma incidence ( J:82649 )
• mice develop gliomas as in Cdkn2atm1Rdp/Cdkn2atm1Rdp Tg(S100b-v-erbB)4496Waw mice with loss of function of the wild-type Cdkn2a allele

nervous system
increased glioma incidence ( J:82649 )
• mice develop gliomas as in Cdkn2atm1Rdp/Cdkn2atm1Rdp Tg(S100b-v-erbB)4496Waw mice with loss of function of the wild-type Cdkn2a allele

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
oligodendroglioma DOID:3181 J:82649




Genotype
MGI:3822319
tg6
Allelic
Composition		 Tg(S100b-v-erbB)4496Waw/0
Genetic
Background		 involves: C57BL/6J * DBA/2J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(S100b-v-erbB)4496Waw mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:82649 )
• within 6 months, 50% of mice die or are euthanized due to glioma development
• after 1 year, 24 of 38 mice (63%) die due to glioma development with the exception of 4 mice that die of unknown causes

neoplasm
increased oligodendroglioma incidence ( J:82649 )
• mice develop oligodendroglioma
• within 6 months, 50% of mice die or are euthanized due to glioma development
• after 1 year, 24 of 38 mice die due to glioma development with the exception of 4 mice that die of unknown causes

nervous system
increased oligodendroglioma incidence ( J:82649 )
• mice develop oligodendroglioma
• within 6 months, 50% of mice die or are euthanized due to glioma development
• after 1 year, 24 of 38 mice die due to glioma development with the exception of 4 mice that die of unknown causes

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
oligodendroglioma DOID:3181 J:82649




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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory