Phenotypes associated with this allele

• Allele Symbol: Fgf23^tm1Tyam
• Allele Name: targeted mutation 1, Takeyoshi Yamashita
• Allele ID: MGI:3033408
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fgf23^tm1Tyam/Fgf23^tm1Tyam	involves: C57BL/6 * CBA	MGI:3033446

Genotype
MGI:3033446

hm1

• Allelic Composition: Fgf23^tm1Tyam/Fgf23^tm1Tyam
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Fgf23^tm1Tyam/Fgf23^tm1Tyam mice display abnormal bone development

mortality/aging

premature death ( J:88172 )

• mice died at various time points after weaning with no mice surviving past 13 weeks of age

growth/size/body

decreased body size ( J:88172 )

decreased body weight ( J:88172 )

postnatal growth retardation ( J:88172 )

hematopoietic system

thymus atrophy ( J:88172 )

• appeared normal at 3 weeks of age, but severe and rapid atrophy ensued after weaning

decreased lymphocyte cell number ( J:88172 )

• reduced number of peripheral lymphocytes relative to heterozygous controls

spleen hypoplasia ( J:88172 )

• appeared normal at 3 weeks of age, but reduction of cells was noted after weaning

homeostasis/metabolism

abnormal blood urea nitrogen level ( J:88172 )

• elevated serum levels

hypoglycemia ( J:88172 )

• first detected at 2 weeks of age

decreased circulating parathyroid hormone level ( J:88172 )

• normal at 10 days and 2 weeks of age, but decreased at 9 and 10 weeks of age

• possibly a result of increased serum levels of calcium and and 1,25(OH)₂D

increased circulating cholesterol level ( J:88172 )

decreased circulating triglyceride level ( J:88172 )

increased circulating calcium level ( J:88172 )

• first significant increase detected at 2 weeks of age

increased circulating phosphate level ( J:88172 )

• first detected at 10 days of age

abnormal renal phosphate reabsorption ( J:88172 )

• enhanced renal phosphate reabsorption

abnormal vitamin D level ( J:88172 )

• increased serum levels of 1,25(OH)₂D due to overexpression of renal 25-hydroxyvitamin D-1alpha-hydroxylase (1alpha-OHase) from 10 days of age

immune system

thymus atrophy ( J:88172 )

• appeared normal at 3 weeks of age, but severe and rapid atrophy ensued after weaning

decreased lymphocyte cell number ( J:88172 )

• reduced number of peripheral lymphocytes relative to heterozygous controls

spleen hypoplasia ( J:88172 )

• appeared normal at 3 weeks of age, but reduction of cells was noted after weaning

limbs/digits/tail

short femur ( J:88172 )

• femurs were markedly shorter than those of controls at 7 weeks of age

renal/urinary system

abnormal renal phosphate reabsorption ( J:88172 )

• enhanced renal phosphate reabsorption

abnormal kidney morphology ( J:88172 )

• marked vascular calcification

abnormal renal glomerulus morphology ( J:88172 )

• atrophy

reproductive system

abnormal reproductive system morphology ( J:88172 )

infertility ( J:88172 )

• due to abnormal development of reproductive organs

skeleton

short femur ( J:88172 )

• femurs were markedly shorter than those of controls at 7 weeks of age

decreased bone mineral density ( J:88172 )

decreased chondrocyte number ( J:88172 )

• severely disorganized growth plate lacking hypertrophic chondrocytes

abnormal skeleton development ( J:88172 )

• accumulation of unmineralized osteoids

endocrine/exocrine glands

thymus atrophy ( J:88172 )

• appeared normal at 3 weeks of age, but severe and rapid atrophy ensued after weaning