Phenotypes associated with this allele

• Allele Symbol: Hfe^tm3Sly
• Allele Name: targeted mutation 3, William S Sly
• Allele ID: MGI:3033462
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hfe^tm3Sly/Hfe^tm3Sly	involves: 129X1/SvJ * C57BL/6J	MGI:3033469
ht2	Hfe^tm2Sly/Hfe^tm3Sly	involves: 129X1/SvJ * C57BL/6J	MGI:3033467

Genotype
MGI:3033469

hm1

• Allelic Composition: Hfe^tm3Sly/Hfe^tm3Sly
• Genetic Background: involves: 129X1/SvJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased liver iron level ( J:88143 )

• increased hepatic iron concentrations in both males and females

• increased relative to Hfe^tm2Sly (H67D)

• iron has a predominantly periportal distribution

liver/biliary system

increased liver iron level ( J:88143 )

• increased hepatic iron concentrations in both males and females

• increased relative to Hfe^tm2Sly (H67D)

• iron has a predominantly periportal distribution

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
hemochromatosis type 1		DOID:0111029	OMIM:235200	J:88143

Genotype
MGI:3033467

ht2

• Allelic Composition: Hfe^tm2Sly/Hfe^tm3Sly
• Genetic Background: involves: 129X1/SvJ * C57BL/6J

homeostasis/metabolism

increased liver iron level ( J:88143 )

• increased hepatic iron concentrations in both males and females

• iron has a predominantly periportal distribution

liver/biliary system

increased liver iron level ( J:88143 )

• increased hepatic iron concentrations in both males and females

• iron has a predominantly periportal distribution

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
hemochromatosis type 1		DOID:0111029	OMIM:235200	J:88143