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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Slc4a2tm1Jmed
targeted mutation 1, Juan F Medina
MGI:3033521
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Slc4a2tm1Jmed/Slc4a2tm1Jmed involves: 129P2/OlaHsd * FVB MGI:3033643
ht2
 		Slc4a2tm1Jmed/Slc4a2+ involves: 129P2/OlaHsd * FVB MGI:3033644


Genotype
MGI:3033643
hm1
Allelic
Composition		 Slc4a2tm1Jmed/Slc4a2tm1Jmed
Genetic
Background		 involves: 129P2/OlaHsd * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc4a2tm1Jmed mutation (0 available); any Slc4a2 mutation (53 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal apoptosis ( J:88196 )
• increased number of apoptotic bodies in the seminiferous tubules and epididymis

endocrine/exocrine glands
decreased Sertoli cell number ( J:88196 )
• existing Sertoli cells exhibited normal morphology
small testis ( J:88196 )
• size and weight reduced by 40% to 60%
testis hypoplasia ( J:88196 )
• reduction in most cell populations
• significant reduction in the number of round spermatids

homeostasis/metabolism
homeostasis/metabolism phenotype ( J:88196 )
N
• normal serum testosterone levels, indicative of normal leydig cell function

reproductive system
decreased Sertoli cell number ( J:88196 )
• existing Sertoli cells exhibited normal morphology
small testis ( J:88196 )
• size and weight reduced by 40% to 60%
testis hypoplasia ( J:88196 )
• reduction in most cell populations
• significant reduction in the number of round spermatids
abnormal spermiogenesis ( J:88196 )
• disruption after stage VII
abnormal epididymis morphology ( J:88196 )
• abnormalities indicative of squamous metaplasia
male infertility ( J:88196 )
• female mice were fertile




Genotype
MGI:3033644
ht2
Allelic
Composition		 Slc4a2tm1Jmed/Slc4a2+
Genetic
Background		 involves: 129P2/OlaHsd * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc4a2tm1Jmed mutation (0 available); any Slc4a2 mutation (53 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:88196 )
• mice were fertile and showed no abnormalities pertaining to the reproductive system
• normal spermiogenesis for both wild-type and mutant haploid germ cells




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory