Analysis Tools|
Allele Symbol Allele Name Allele ID |
Icmttm1Mbrg targeted mutation 1, Martin O Bergo MGI:3033709 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• photoreceptors show a slow and progressive loss of 3 or 4 nuclear layers by P160
• however, photoreceptor development is normal
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• slow and progressive photoreceptor degeneration by P160
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• ERG shows that light-evoked response is progressively reduced in retinas by P160
• cones exhibit a greater functional loss than rods
• however, no changes in rod or cone responses are seen at P24
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• rod responses progressively decline with age, with maximal rod responses reduced by 82% at P160
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• cone responses are reduced by 92% at P160
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• progressive loss of vision
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• slow and progressive photoreceptor degeneration by P160
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• hepatocytes with a disrupted alleles proliferate more slowly than those with an intact alleles
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 10/09/2024 MGI 6.24 |
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