mortality/aging
• 48% mortality from LPS-induced shock compared to 15% of wild-type mice
• higher mortality from bacterial septic shock than controls
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cardiovascular system
• while blood pressure is normal in conscious mutants, it is reduced relative to that of wild-type controls in mutants under anesthesia
• associated with increases in basal levels of S-nitrosothiol (SNO)
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homeostasis/metabolism
• in induced endotoxic shock, metabolism of endogenously generated nitrosothiols is severely impaired
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• reduced blood pressure relative to wild-type controls after administration of urethane anesthetic
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immune system
• increased S-nitrosylation, tissue damage, and mortality following LPS-challenge and induced sepsis
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• 48% mortality from LPS-induced shock compared to 15% of wild-type mice
• higher mortality from bacterial septic shock than controls
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