Phenotypes associated with this allele

• Allele Symbol: Strbp^{Gt(pGT1.8geo)8Pgr}
• Allele Name: gene trap 8, Peter Gruss
• Allele ID: MGI:3033751
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Strbp^Gt(pGT1.8geo)8Pgr/Strbp^Gt(pGT1.8geo)8Pgr	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	MGI:3034015

Genotype
MGI:3034015

hm1

• Allelic Composition: Strbp^{Gt(pGT1.8geo)8Pgr}/Strbp^{Gt(pGT1.8geo)8Pgr}
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:69466 )

• incomplete penetrance; 43% of homozygotes die prematurely

postnatal lethality, incomplete penetrance ( J:69466 )

• incomplete penetrance; approximately one third of homozygous mice die by 1 week of age

behavior/neurological

limb grasping ( J:69466 )

• animals clasp limbs together when lifted by the tail instead of splaying limbs

reduced male mating frequency ( J:69466 )

♂ • males rarely initiate mating behavior

endocrine/exocrine glands

abnormal seminiferous tubule epithelium morphology ( J:69466 )

♂ • thin seminiferous epithelium

decreased testis weight ( J:69466 )

♂

growth/size/body

decreased body weight ( J:69466 )

• average weight of homozygotes is 63.8% of controls

reproductive system

asthenozoospermia ( J:69466 )

♂

abnormal seminiferous tubule epithelium morphology ( J:69466 )

♂ • thin seminiferous epithelium

decreased testis weight ( J:69466 )

♂

abnormal spermatogenesis ( J:69466 )

♂ • degenerated germ cells in various stages were noted; reduced numbers of mature spermatozoa were observed

oligozoospermia ( J:69466 )

♂ • reduced sperm count; homozygous mice had half the number of sperm as controls; in some cases no sperm were present

decreased litter size ( J:69466 )

• successful pregnancies from homozygous males resulted in an average litter size of 2; controls had 6 or 7

reduced male fertility ( J:69466 )

♂ • of successful matings by homozygous males, only 40% of plugged females led to pregnancy

nervous system

abnormal superior colliculus morphology ( J:69466 )

• the superior colliculi in homozygous brains were more exposed than in controls

cellular

oligozoospermia ( J:69466 )

♂ • reduced sperm count; homozygous mice had half the number of sperm as controls; in some cases no sperm were present

asthenozoospermia ( J:69466 )

♂