All Phenotypes Vsx1<tm1Mci> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Vsx1^tm1Mci
targeted mutation 1, Roderick R McInnes
MGI:3033929

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Vsx1^tm1Mci/Vsx1^tm1Mci	either: (involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * Black Swiss)	MGI:3033934
cx2	Irx6^tm1Chow/Irx6^tm1Chow Vsx1^tm1Mci/Vsx1^tm1Mci	involves: 129S1/Sv * 129S1/SvImj * 129X1/SvJ	MGI:5448239

Allelic Composition	Vsx1^tm1Mci/Vsx1^tm1Mci
Genetic Background	either: (involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * Black Swiss)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Vsx1^tm1Mci mutation (0 available); any Vsx1 mutation (11 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

vision/eye phenotype ( J:88182 )

N	• no corneal defects were observed, either grossly or histologically

abnormal retina cone bipolar cell morphology ( J:88182 )

• incomplete terminal differentiation of OFF-cone bipolar cells in the retina as indicated by a reduction in expression of several markers

abnormal eye electrophysiology ( J:88182 )

• reduced b-wave amplitude in response to white flashes

• putatively associated with incomplete differentiation and function of OFF cone bipolar cells

nervous system

abnormal retina cone bipolar cell morphology ( J:88182 )

• incomplete terminal differentiation of OFF-cone bipolar cells in the retina as indicated by a reduction in expression of several markers

behavior/neurological

behavior/neurological phenotype ( J:88182 )

N	• no overt behavioral or neurological phenotypes observed

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
NOT	keratoconus	DOID:10126	OMIM:148300 OMIM:608586 OMIM:608932 OMIM:609271 OMIM:614622 OMIM:614623 OMIM:614628 OMIM:614629	J:88182

Allelic Composition	Irx6^tm1Chow/Irx6^tm1Chow Vsx1^tm1Mci/Vsx1^tm1Mci
Genetic Background	involves: 129S1/Sv * 129S1/SvImj * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irx6^tm1Chow mutation (0 available); any Irx6 mutation (27 available)
Vsx1^tm1Mci mutation (0 available); any Vsx1 mutation (11 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal retina bipolar cell morphology ( J:189955 )

• all Hcn4 expressing cells also express Tacr3, unlike in wild-type controls

nervous system

abnormal retina bipolar cell morphology ( J:189955 )

• all Hcn4 expressing cells also express Tacr3, unlike in wild-type controls

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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