All Phenotypes Hsf1<tm1Miv> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hsf1^tm1Miv/Hsf1^tm1Miv	involves: 129S2/SvPas * C57BL/6	MGI:3033964
cx2	Hsf1^tm1Miv/Hsf1^tm1Miv Hsf2^tm1Miv/Hsf2^tm1Miv	involves: 129S2/SvPas * 129X1/SvJ * C57BL/6	MGI:3033965

Allelic Composition	Hsf1^tm1Miv/Hsf1^tm1Miv
Genetic Background	involves: 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hsf1^tm1Miv mutation (0 available); any Hsf1 mutation (25 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal cell death ( J:88534 )

• increased sensitivity to heat stress was seen in bone marrow cells and fibroblasts

decreased sensitivity to induced cell death ( J:88534 )

• mouse embryo fibroblasts have an increased sensitivity to many apoptosis inducing agents

reproductive system

female infertility ( J:88534 )

• although homozygous females are infertile, homozygous males are normal

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Testes are smaller in Hsf2^tm1Miv/Hsf2^tm1Miv and Hsf1^tm1Miv/Hsf1^tm1Miv Hsf2^tm1Miv/Hsf2^tm1Miv mice

cellular

azoospermia ( J:88035 )

• total lack of sperm in seminal fluid

multinucleated giant male germ cells ( J:88035 )

arrest of male meiosis ( J:88035 )

• the most advanced germ cells present are spermatogonia and pachytene spermatocytes indicating male meiosis does not progress beyond prophase I

mortality/aging

prenatal lethality, incomplete penetrance ( J:88035 )

• reduced numbers of double homozygotes are born

endocrine/exocrine glands

abnormal testis morphology ( J:88035 )

abnormal seminiferous tubule morphology ( J:88035 )

• large vacuolated structures and large multinucleated giant cells found in tubules

• large numbers of apoptotic cells in tubules of testes

small testis ( J:88035 )

• less than 50% of wild-type

growth/size/body

decreased body size ( J:88035 )

• reduced by about 20% compared to wild-type

decreased body weight ( J:88035 )