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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		hem6
hematology 6
MGI:3034014
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		hem6/hem6 involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 MGI:3822520
hm2
 		hem6/hem6 Not Specified MGI:3046532
cx3
 		Fechm1Pas/Fechm1Pas
hem6/hem6+ 		involves: 129 * BALB/c * C57BL/6 MGI:3822521
cx4
 		Fechm1Pas/Fechm1Pas
hem6/hem6 		involves: 129 * BALB/c * C57BL/6 MGI:3822522


Genotype
MGI:3822520
hm1
Allelic
Composition		 hem6/hem6
Genetic
Background		 involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
hem6 mutation (1 available); any hem6 mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
teratozoospermia ( J:142791 )
• abnormal cytoplasmic reduction of the neck of terminally differentiating spermatozoa leads to structural fragility
asthenozoospermia ( J:142791 )
• sperm have reduced motility

hematopoietic system
hypochromic microcytic anemia ( J:142791 )
• mice are hypochromic with mildy microcytic blood cells
high mean erythrocyte cell number ( J:142791 )
• mean erythrocyte number is increased in mice at both 4 and 12 weeks of age compared to controls
decreased hemoglobin content ( J:142791 )
• hemoglobin concentration of the blood is lower at both 4 and 12 weeks of age though iron levels in the liver and blood are normal
decreased mean corpuscular hemoglobin concentration ( J:142791 )
• mean corpuscular volume is significantly decreased at both 4 and 12 weeks of age
decreased mean corpuscular volume ( J:142791 )
• mean corpuscular volume is significantly decreased at both 4 and 12 weeks of age
abnormal reticulocyte morphology ( J:142791 )
• reticulocytes have decreased hemoglobin concentration
• the heme-iron to whole cell iron ratio is half that of wild-type mice though iron uptake by reticulocytes is normal
abnormal hematopoietic system physiology ( J:142791 )
• hypochromic microcytic anemia is transferable when mutant E15.5 fetal liver hematopoietic stem cells from E15.5 are transferred to an irradiated host

homeostasis/metabolism
abnormal homeostasis ( J:142791 )
• there is a decrease in the zinc protoporphyrin IX to heme (ZnPP/H) ratio in erythrocytes with ZnPP/H being only two-thirds of that found in wild-type controls at 24 weeks of age

reproductive system
teratozoospermia ( J:142791 )
• abnormal cytoplasmic reduction of the neck of terminally differentiating spermatozoa leads to structural fragility
asthenozoospermia ( J:142791 )
• sperm have reduced motility
male infertility ( J:142791 )
• males are infertile




Genotype
MGI:3046532
hm2
Allelic
Composition		 hem6/hem6
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
hem6 mutation (1 available); any hem6 mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system




Genotype
MGI:3822521
cx3
Allelic
Composition		 Fechm1Pas/Fechm1Pas
hem6/hem6+
Genetic
Background		 involves: 129 * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fechm1Pas mutation (2 available); any Fech mutation (24 available)
hem6 mutation (1 available); any hem6 mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased hemoglobin content ( J:142791 )
• hemoglobulin content is reduced by around 20%
increased erythrocyte protoporphyrin level ( J:142791 )
• mice have dramatically elevated levels of protoporphyrin IX (PPIX) in erythrocytes with 41.5% of erythrocytes being fluorescent, which is indicative of high levels of PPIX

homeostasis/metabolism
increased erythrocyte protoporphyrin level ( J:142791 )
• mice have dramatically elevated levels of protoporphyrin IX (PPIX) in erythrocytes with 41.5% of erythrocytes being fluorescent, which is indicative of high levels of PPIX

liver/biliary system
increased liver weight ( J:142791 )
• liver weight-to-body weight ratio is three times that of controls due to hepatic porphyrin accumulation

growth/size/body
increased liver weight ( J:142791 )
• liver weight-to-body weight ratio is three times that of controls due to hepatic porphyrin accumulation




Genotype
MGI:3822522
cx4
Allelic
Composition		 Fechm1Pas/Fechm1Pas
hem6/hem6
Genetic
Background		 involves: 129 * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fechm1Pas mutation (2 available); any Fech mutation (24 available)
hem6 mutation (1 available); any hem6 mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased hemoglobin content ( J:142791 )
• hemoglobulin content is reduced almost by a third compared to controls
increased erythrocyte protoporphyrin level ( J:142791 )
• mice have slightly elevated levels of protoporphyrin IX (PPIX) in erythrocytes with 4.16% of erythrocytes being fluorescent, which is indicative of high levels of PPIX
• in comparison, 41.6% of erythrocytes from Fechm1Pas homozygotes fluoresce while only 0.08% of wild-type erythrocytes fluoresce

homeostasis/metabolism
increased erythrocyte protoporphyrin level ( J:142791 )
• mice have slightly elevated levels of protoporphyrin IX (PPIX) in erythrocytes with 4.16% of erythrocytes being fluorescent, which is indicative of high levels of PPIX
• in comparison, 41.6% of erythrocytes from Fechm1Pas homozygotes fluoresce while only 0.08% of wild-type erythrocytes fluoresce




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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory