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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Nfkbietm1Syme
targeted mutation 1, Sylvie Memet
MGI:3034029
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Nfkbietm1Syme/Nfkbietm1Syme either: (involves: 129P2/OlaHsd * C57BL/6 * DBA/2) or (involves: 129P2/OlaHsd * C57BL/6) MGI:3034063
cx2
 		Nfkbiatm1Bal/Nfkbiatm1Bal
Nfkbietm1Syme/Nfkbietm1Syme 		involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA/2 MGI:3053046


Genotype
MGI:3034063
hm1
Allelic
Composition		 Nfkbietm1Syme/Nfkbietm1Syme
Genetic
Background		 either: (involves: 129P2/OlaHsd * C57BL/6 * DBA/2) or (involves: 129P2/OlaHsd * C57BL/6)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfkbietm1Syme mutation (0 available); any Nfkbie mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal double-negative T cell morphology ( J:88538 )
• 50% reduction of CD44-/CD25+ double negative cells
• only lymphocyte abnormality
increased IgG1 level ( J:88538 )
• IgG1 levels increased 3X
increased IgM level ( J:88538 )
• 2 fold increase

immune system
abnormal double-negative T cell morphology ( J:88538 )
• 50% reduction of CD44-/CD25+ double negative cells
• only lymphocyte abnormality
increased IgG1 level ( J:88538 )
• IgG1 levels increased 3X
increased IgM level ( J:88538 )
• 2 fold increase

skeleton
skeleton phenotype ( J:88538 )
N
• skeleton was normal




Genotype
MGI:3053046
cx2
Allelic
Composition		 Nfkbiatm1Bal/Nfkbiatm1Bal
Nfkbietm1Syme/Nfkbietm1Syme
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfkbiatm1Bal mutation (1 available); any Nfkbia mutation (19 available)
Nfkbietm1Syme mutation (0 available); any Nfkbie mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, complete penetrance ( J:88142 )
• double homozygotes are born alive but remain cyanotic and die within 10-30 minutes

hematopoietic system
increased B cell apoptosis ( J:88142 )
• increased among B cells
increased T cell apoptosis ( J:88142 )
• increased among T cells in transition from double positive to single positive
abnormal B cell differentiation ( J:88142 )
• decreased numbers of B cell precursors
decreased immature B cell number ( J:88142 )
• very low numbers of immature B cells
abnormal T cell differentiation ( J:88142 )
• development from the double positive stage to the single positive stage is reduced
decreased pre-B cell number ( J:88142 )
• clear reduction of B220+CD43- cells

immune system
increased B cell apoptosis ( J:88142 )
• increased among B cells
increased T cell apoptosis ( J:88142 )
• increased among T cells in transition from double positive to single positive
abnormal B cell differentiation ( J:88142 )
• decreased numbers of B cell precursors
decreased immature B cell number ( J:88142 )
• very low numbers of immature B cells
abnormal T cell differentiation ( J:88142 )
• development from the double positive stage to the single positive stage is reduced
decreased pre-B cell number ( J:88142 )
• clear reduction of B220+CD43- cells

cellular
increased B cell apoptosis ( J:88142 )
• increased among B cells
increased T cell apoptosis ( J:88142 )
• increased among T cells in transition from double positive to single positive




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
07/05/2024
MGI 6.24 		The Jackson Laboratory