About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Nfkbietm1Syme
targeted mutation 1, Sylvie Memet
MGI:3034029
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Nfkbietm1Syme/Nfkbietm1Syme either: (involves: 129P2/OlaHsd * C57BL/6 * DBA/2) or (involves: 129P2/OlaHsd * C57BL/6) MGI:3034063
cx2
 		Nfkbiatm1Bal/Nfkbiatm1Bal
Nfkbietm1Syme/Nfkbietm1Syme 		involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA/2 MGI:3053046


Genotype
MGI:3034063
hm1
Allelic
Composition		 Nfkbietm1Syme/Nfkbietm1Syme
Genetic
Background		 either: (involves: 129P2/OlaHsd * C57BL/6 * DBA/2) or (involves: 129P2/OlaHsd * C57BL/6)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfkbietm1Syme mutation (0 available); any Nfkbie mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal double-negative T cell morphology ( J:88538 )
• 50% reduction of CD44-/CD25+ double negative cells
• only lymphocyte abnormality
increased IgG1 level ( J:88538 )
• IgG1 levels increased 3X
increased IgM level ( J:88538 )
• 2 fold increase

immune system
abnormal double-negative T cell morphology ( J:88538 )
• 50% reduction of CD44-/CD25+ double negative cells
• only lymphocyte abnormality
increased IgG1 level ( J:88538 )
• IgG1 levels increased 3X
increased IgM level ( J:88538 )
• 2 fold increase

skeleton
skeleton phenotype ( J:88538 )
N
• skeleton was normal




Genotype
MGI:3053046
cx2
Allelic
Composition		 Nfkbiatm1Bal/Nfkbiatm1Bal
Nfkbietm1Syme/Nfkbietm1Syme
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfkbiatm1Bal mutation (1 available); any Nfkbia mutation (19 available)
Nfkbietm1Syme mutation (0 available); any Nfkbie mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, complete penetrance ( J:88142 )
• double homozygotes are born alive but remain cyanotic and die within 10-30 minutes

hematopoietic system
increased B cell apoptosis ( J:88142 )
• increased among B cells
increased T cell apoptosis ( J:88142 )
• increased among T cells in transition from double positive to single positive
abnormal B cell differentiation ( J:88142 )
• decreased numbers of B cell precursors
decreased immature B cell number ( J:88142 )
• very low numbers of immature B cells
abnormal T cell differentiation ( J:88142 )
• development from the double positive stage to the single positive stage is reduced
decreased pre-B cell number ( J:88142 )
• clear reduction of B220+CD43- cells

immune system
increased B cell apoptosis ( J:88142 )
• increased among B cells
increased T cell apoptosis ( J:88142 )
• increased among T cells in transition from double positive to single positive
abnormal B cell differentiation ( J:88142 )
• decreased numbers of B cell precursors
decreased immature B cell number ( J:88142 )
• very low numbers of immature B cells
abnormal T cell differentiation ( J:88142 )
• development from the double positive stage to the single positive stage is reduced
decreased pre-B cell number ( J:88142 )
• clear reduction of B220+CD43- cells

cellular
increased B cell apoptosis ( J:88142 )
• increased among B cells
increased T cell apoptosis ( J:88142 )
• increased among T cells in transition from double positive to single positive




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory