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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tlr6tm1Aki
targeted mutation 1, Shizuo Akira
MGI:3034062
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tlr6tm1Aki/Tlr6tm1Aki involves: 129P2/OlaHsd * C57BL/6 MGI:3034072
cx2
 		Tlr2tm1Aki/Tlr2tm1Aki
Tlr6tm1Aki/Tlr6tm1Aki 		involves: 129P2/OlaHsd * C57BL/6 MGI:4456174


Genotype
MGI:3034072
hm1
Allelic
Composition		 Tlr6tm1Aki/Tlr6tm1Aki
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tlr6tm1Aki mutation (1 available); any Tlr6 mutation (50 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal macrophage physiology ( J:70578 )
• macrophages are unresponsive to macrophage activating lipopeptide 2 kD (MALP-2)
• normal response of macrophages to lipopeptides of other bacterial origins
abnormal cytokine secretion ( J:70578 )
• cytokine production by macrophages in response to diacylated (macrophage activating lipopeptide 2 kD [MALP-2]), but not to tiracylated, lipopeptides is completely abrogated
decreased interleukin-12 secretion ( J:70578 )
• macrophages produce no NO and IL-12 in response to MALP-2 together with IFN-gamma
decreased interleukin-6 secretion ( J:70578 )
• MEFs treated with MALP-2 fail to produce IL-6
decreased tumor necrosis factor secretion ( J:70578 )
• macrophages produce no TNF-alpha in response to MALP-2
• macrophages show impaired TNF-alpha production in response to heat-killed mycoplasma

hematopoietic system
abnormal macrophage physiology ( J:70578 )
• macrophages are unresponsive to macrophage activating lipopeptide 2 kD (MALP-2)
• normal response of macrophages to lipopeptides of other bacterial origins




Genotype
MGI:4456174
cx2
Allelic
Composition		 Tlr2tm1Aki/Tlr2tm1Aki
Tlr6tm1Aki/Tlr6tm1Aki
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tlr2tm1Aki mutation (7 available); any Tlr2 mutation (60 available)
Tlr6tm1Aki mutation (1 available); any Tlr6 mutation (50 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased interleukin-6 secretion ( J:70578 )
• MEFs treated with diacylated (macrophage activating lipopeptide 2 kD [MALP-2]) and triacylated lipopeptides (tripalitoyl cysteinyl lipopeptide [Pam3CSK4]) fail to produce IL-6




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory