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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Grip1tm1Rha
targeted mutation 1, Ralf H Adams
MGI:3035931
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Grip1tm1Rha/Grip1tm1Rha B6.129-Grip1tm1Rha MGI:3035937
hm2
Grip1tm1Rha/Grip1tm1Rha involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3035936
cx3
Grip1tm1Rha/Grip1tm1Rha
Grip2tm1Rha/Grip2tm1Rha
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3035949


Genotype
MGI:3035937
hm1
Allelic
Composition
Grip1tm1Rha/Grip1tm1Rha
Genetic
Background
B6.129-Grip1tm1Rha
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grip1tm1Rha mutation (1 available); any Grip1 mutation (93 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• Background Sensitivity: mice that had been backcrossed to C57BL/6 for 6 generations develop to term

limbs/digits/tail
• observed in hindlimbs of mice that developed to E16.5
• observed in hindlimbs of mice that developed to E16.5

renal/urinary system
• at E13.5, unstructured mesenchymal rudiments devoid of metanephric tubules and containing large numbers of apoptotic cells

integument
• formation of large subepidermal blisters underneath the epidermal basement membrane of the head, limb, and back skin
• initially transparent when first observed at E11, but blisters became hemorrhagic
• blisters subsided in mice that survived to late gestation

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Fraser syndrome DOID:0090001 OMIM:PS219000
J:88266




Genotype
MGI:3035936
hm2
Allelic
Composition
Grip1tm1Rha/Grip1tm1Rha
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grip1tm1Rha mutation (1 available); any Grip1 mutation (93 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• Background Sensitivity: mice that had been backcrossed to C57BL/6 for 6 generations develop to term
• Background Sensitivity: most mice on a mixed background involving both 129 and C57BL/6 died around E13.5




Genotype
MGI:3035949
cx3
Allelic
Composition
Grip1tm1Rha/Grip1tm1Rha
Grip2tm1Rha/Grip2tm1Rha
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grip1tm1Rha mutation (1 available); any Grip1 mutation (93 available)
Grip2tm1Rha mutation (1 available); any Grip2 mutation (35 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
limbs/digits/tail
• observed in hindlimbs

vision/eye
• both unilateral and bilateral cryptophtalmos was observed

integument
N
• no externally visible blisters





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/19/2024
MGI 6.24
The Jackson Laboratory