mortality/aging
N |
• Background Sensitivity: mice that had been backcrossed to C57BL/6 for 6 generations develop to term
|
limbs/digits/tail
polydactyly
(
J:88266
)
• observed in hindlimbs of mice that developed to E16.5
|
syndactyly
(
J:88266
)
• observed in hindlimbs of mice that developed to E16.5
|
renal/urinary system
• at E13.5, unstructured mesenchymal rudiments devoid of metanephric tubules and containing large numbers of apoptotic cells
|
absent kidney
(
J:88266
)
integument
blistering
(
J:88266
)
• formation of large subepidermal blisters underneath the epidermal basement membrane of the head, limb, and back skin
• initially transparent when first observed at E11, but blisters became hemorrhagic
• blisters subsided in mice that survived to late gestation
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
Fraser syndrome | DOID:0090001 |
OMIM:PS219000 |
J:88266 |