All Phenotypes Grip2<tm1Rha> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Grip2^tm1Rha
targeted mutation 1, Ralf H Adams
MGI:3035933

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Grip2^tm1Rha/Grip2^tm1Rha	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3035934
cx2	Grip1^tm1Rha/Grip1^tm1Rha Grip2^tm1Rha/Grip2^tm1Rha	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3035949
cx3	Grip1^tm1Rlh/Grip1^tm1Rlh Grip2^tm1Rha/Grip2^tm1Rha	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL	MGI:3805832

Allelic Composition	Grip2^tm1Rha/Grip2^tm1Rha
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grip2^tm1Rha mutation (1 available); any Grip2 mutation (35 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:136388 )

N	• cultured cortical neurons show normal long term depression induced by glutamate/depolarization pairing or by phorbol ester chemical treatment

Allelic Composition	Grip1^tm1Rha/Grip1^tm1Rha Grip2^tm1Rha/Grip2^tm1Rha
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grip1^tm1Rha mutation (1 available); any Grip1 mutation (93 available)
Grip2^tm1Rha mutation (1 available); any Grip2 mutation (35 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

syndactyly ( J:88266 )

• observed in hindlimbs

vision/eye

cryptophthalmos ( J:88266 )

• both unilateral and bilateral cryptophtalmos was observed

integument

integument phenotype ( J:88266 )

N	• no externally visible blisters

Allelic Composition	Grip1^tm1Rlh/Grip1^tm1Rlh Grip2^tm1Rha/Grip2^tm1Rha
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grip1^tm1Rlh mutation (1 available); any Grip1 mutation (93 available)
Grip2^tm1Rha mutation (1 available); any Grip2 mutation (35 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

absent long-term depression ( J:136388 )

• after glutamate/repolarization pairing treatment to induce long term depression, LTD is abolished in cultured neurons from double mutants that were transfected with lentiviral EGFP-IRES-Cre to produce conditional deletion of Grip1

• chemical LTD produced by treatment with a PKC-activating phorbol ester is also abolished in double null mutants in contrast to controls or single Grip1- or Grip2-null mice

• Purkinje cells transfected with a plasmid overexpressing Grip1 show complete rescue of pairing- and chemical-induced LTD; overexpression of Grip2 in Purkinje cells results in only partial rescue of LTD

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