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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Il23atm1Ngh
targeted mutation 1, Nico Ghilardi
MGI:3036163
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Il23atm1Ngh/Il23atm1Ngh involves: 129 MGI:4459520
hm2
Il23atm1Ngh/Il23atm1Ngh involves: 129 * C57BL/6 MGI:3713196
hm3
Il23atm1Ngh/Il23atm1Ngh involves: 129S/SvEv * C57BL/6 MGI:3036166
cn4
Apctm1Tno/Apc+
Il23atm1Ngh/Il23atm1Ngh
Tg(CDX2-cre)101Erf/0
involves: 129 * 129S4/SvJae * C57BL/6J * SJL/J MGI:5446624


Genotype
MGI:4459520
hm1
Allelic
Composition
Il23atm1Ngh/Il23atm1Ngh
Genetic
Background
involves: 129
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il23atm1Ngh mutation (0 available); any Il23a mutation (27 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• died from around day 10 to day 14 after inoculation with C. rodentium

immune system
• died from around day 10 to day 14 after inoculation with C. rodentium




Genotype
MGI:3713196
hm2
Allelic
Composition
Il23atm1Ngh/Il23atm1Ngh
Genetic
Background
involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il23atm1Ngh mutation (0 available); any Il23a mutation (27 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
digestive/alimentary system
• decreased leukocyte infiltration
• less crypt loss
• reduced epithelial hyperplasia
• less colon shortening

immune system
• less colon shortening
• decreased leukocyte infiltration
• less crypt loss
• reduced epithelial hyperplasia
• 15 days after aerosol challenge with M. tuberculosis, mice produce less CD4+ T cells with an activated CD44hiCXCR3+ phenotype than wild-type
• following vaccination against M. tuberculosis, mice do not lower bacterial burden in the lung 30 days after challenge and fail to elicit an accelerated IFN-gamma or IL-17 T cell recall response
• low levels of IL22 after DSS treatment
• increase in levels after DSS treatment is less than for controls
• 15 days after aerosol challenge with M. tuberculosis, mice fail to produce mononuclear granulomatous structures as wild-type mice do
• following vaccination against M. tuberculosis, mice do not lower bacterial burden in the lung 30 days after challenge and fail to elicit an accelerated IFN-gamma or IL-17 T cell recall response
• 15 days after aerosol challenge with M. tuberculosis, mice fail to produce mononuclear granulomatous structures as wild-type mice do
• 15 days after aerosol challenge with M. tuberculosis, mice produce less CD4+ T cells with an activated CD44hiCXCR3+ phenotype than wild-type mice

hematopoietic system
• 15 days after aerosol challenge with M. tuberculosis, mice produce less CD4+ T cells with an activated CD44hiCXCR3+ phenotype than wild-type
• following vaccination against M. tuberculosis, mice do not lower bacterial burden in the lung 30 days after challenge and fail to elicit an accelerated IFN-gamma or IL-17 T cell recall response

homeostasis/metabolism
• low levels of IL22 after DSS treatment
• increase in levels after DSS treatment is less than for controls
• significantly less weight loss after treatment with Sodium Dextran Sulfate (DSS) than in controls




Genotype
MGI:3036166
hm3
Allelic
Composition
Il23atm1Ngh/Il23atm1Ngh
Genetic
Background
involves: 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il23atm1Ngh mutation (0 available); any Il23a mutation (27 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• a slight but significant skewing of cell populations toward CD8+ phenotype
• after a second immunization, all OVA specific Ig isotypes were reduced relative to controls
• OVA specific IgA levels were reduced relative to controls after primary immunization
• OVA specific IgG2a levels were reduced relative to controls after primary immunization
• inefficient responses by CD4+ T cells
• defect in memory T cell activation

immune system
• a slight but significant skewing of cell populations toward CD8+ phenotype
• after a second immunization, all OVA specific Ig isotypes were reduced relative to controls
• OVA specific IgA levels were reduced relative to controls after primary immunization
• OVA specific IgG2a levels were reduced relative to controls after primary immunization
• inefficient responses by CD4+ T cells
• defect in memory T cell activation




Genotype
MGI:5446624
cn4
Allelic
Composition
Apctm1Tno/Apc+
Il23atm1Ngh/Il23atm1Ngh
Tg(CDX2-cre)101Erf/0
Genetic
Background
involves: 129 * 129S4/SvJae * C57BL/6J * SJL/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apctm1Tno mutation (6 available); any Apc mutation (158 available)
Il23atm1Ngh mutation (0 available); any Il23a mutation (27 available)
Tg(CDX2-cre)101Erf mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• reduced colorectal tumor multiplicity and grown due to reduced cell proliferation compared with Apctm1Tno/Apc+ Tg(CDX2-cre)101Erf mice





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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory