All Phenotypes Tcf4<tm1Hmb> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Tcf4^tm1Hmb/Tcf4^tm1Zhu Tg(Kit-cre)143Hmb/?	involves: 129P2/OlaHsd * C57BL/6 * CBA	MGI:3719236
cn2	Tcf4^tm1Hmb/Tcf4⁺ Tmem163^{Tg(ACTB-cre)2Mrt}/Tmem163⁺	involves: 129P2/OlaHsd * C57BL/6 * FVB/N	MGI:6157967
cn3	Tcf4^tm1Hmb/Tcf4⁺ Tg(Nes-cre)1Kln/0	involves: 129P2/OlaHsd * C57BL/6 * SJL	MGI:6157968

Allelic Composition	Tcf4^tm1Hmb/Tcf4^tm1Zhu Tg(Kit-cre)143Hmb/?
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcf4^tm1Hmb mutation (0 available); any Tcf4 mutation (58 available)
Tcf4^tm1Zhu mutation (0 available); any Tcf4 mutation (58 available)
Tg(Kit-cre)143Hmb mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

decreased thymocyte number ( J:65236 )

• fewer thymocytes with the Tcf4^tm1Hmb allele are detected

abnormal B cell differentiation ( J:65236 )

• fewer B220-CD3- B cells with the Tcf4^tm1Hmb allele are detected

decreased double-positive T cell number ( J:65236 )

• fewer immature CD4+CD8+ T cells with the Tcf4^tm1Hmb allele are detected

spleen hypoplasia ( J:65236 )

• fewer splenocytes with the Tcf4^tm1Hmb allele are detected

immune system

decreased thymocyte number ( J:65236 )

• fewer thymocytes with the Tcf4^tm1Hmb allele are detected

abnormal B cell differentiation ( J:65236 )

• fewer B220-CD3- B cells with the Tcf4^tm1Hmb allele are detected

decreased double-positive T cell number ( J:65236 )

• fewer immature CD4+CD8+ T cells with the Tcf4^tm1Hmb allele are detected

spleen hypoplasia ( J:65236 )

• fewer splenocytes with the Tcf4^tm1Hmb allele are detected

endocrine/exocrine glands

decreased thymocyte number ( J:65236 )

• fewer thymocytes with the Tcf4^tm1Hmb allele are detected

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body weight ( J:254983 )

behavior/neurological

abnormal habituation to a new environment ( J:254983 )

• mice show a similar level of activity at the outset of the task as controls, but the level of activity appears to wane more slowly, indicating a possible deficit in habituation to novel environments

impaired spatial learning ( J:254983 )

• mice take a longer time to locate the hidden platform in the Morris water maze task and travel farther during the acquisition phase than controls

• during the reversal phase of the hidden platform test, mice never meet the criterion for learning across the entire regimen, and they travel farther than controls

decreased anxiety-related response ( J:254983 )

• mice spend more time in the center region of the novel open field during the last 20 min of the trial, indicating reduced anxiety

• in the elevated plus maze task, mice spend more time in the open arms and make more entries into the open arm than closed arm, indicating reduced anxiety

decreased startle reflex ( J:254983 )

• mice exhibit a reduced startle to a 74 dB stimulus at both 12 and 19 weeks of age

increased locomotor activity ( J:254983 )

• mice exhibit increased activity and total distance traveled in the open field task

• however, mice exhibit normal motor coordination in the accelerating rotarod and normal sociability in the three-chamber task

nervous system

enhanced NMDA-mediated synaptic currents ( J:254983 )

• NMDA/AMPA current ratio is enhanced and because AMPA receptor-mediated synaptic transmission appears intact, this suggests that NMDAR-mediated currents are selectively enhanced

enhanced long-term potentiation ( J:254983 )

• mice exhibit enhanced long term potentiation (LTP) after 3 1 second bursts of 100 Hz stimulation and LTP is consistently enhanced over a range of stimulation frequencies

• however, no differences are seen in long term depression (LTD) after 15 min of 1 Hz stimulation, presynaptic function and AMPA receptor-mediated synaptic transmission appear normal in hippocampal area CA1, and short-term plasticity in terms of the paired-pulse ratio appears normal

decreased prepulse inhibition ( J:254983 )

• percentage prepulse inhibition is decreased in 19 week old mice but not 12-week old mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Pitt-Hopkins syndrome		DOID:0060488	OMIM:610954	J:254983

Allelic Composition	Tcf4^tm1Hmb/Tcf4⁺ Tg(Nes-cre)1Kln/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcf4^tm1Hmb mutation (0 available); any Tcf4 mutation (58 available)
Tg(Nes-cre)1Kln mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body weight ( J:254983 )

microcephaly ( J:254983 )

nervous system

abnormal brain morphology ( J:254983 )

• reduction in brain volume

decreased brain weight ( J:254983 )

enhanced long-term potentiation ( J:254983 )

• mice exhibit enhanced long term potentiation (LTP) after 3 1 second bursts of 100 Hz stimulation and LTP is consistently enhanced over a range of stimulation frequencies

• however, no differences in long term depression (LTD) after 15 min of 1 Hz stimulation are seen, presynaptic function and AMPA receptor-mediated synaptic transmission appear normal in hippocampal area CA1, and short-term plasticity in terms of the paired-pulse ratio appears normal

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Pitt-Hopkins syndrome		DOID:0060488	OMIM:610954	J:254983

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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