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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Lck)4220Rmp
transgene insertion 3073, Roger M Perlmutter
MGI:3036300
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Ccnd3tm1Pisc/Ccnd3tm1Pisc
Tg(Lck)4220Rmp/0 		involves: C57BL/6J * DBA/2 MGI:3036302
tg2
 		Tg(Lck)4220Rmp/0 involves: C57BL/6J * DBA/2 MGI:3036305


Genotype
MGI:3036302
cx1
Allelic
Composition		 Ccnd3tm1Pisc/Ccnd3tm1Pisc
Tg(Lck)4220Rmp/0
Genetic
Background		 involves: C57BL/6J * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccnd3tm1Pisc mutation (0 available); any Ccnd3 mutation (507 available)
Tg(Lck)4220Rmp mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
decreased tumor-free survival time ( J:88120 )
• mice develop T cell tumors and die starting at 13-15 weeks of age with 100% mortality observed by 22 weeks

neoplasm
increased T cell derived lymphoma incidence ( J:88120 )
• mice develop T cell malignancies starting at 13-15 weeks
decreased lymphoma incidence ( J:88120 )
• tumor formation is delayed 6-8 weeks compared to Ccnd3-sufficient, Tg(Lck)4220Rmp-expressing animals

endocrine/exocrine glands
increased T cell derived lymphoma incidence ( J:88120 )
• mice develop T cell malignancies starting at 13-15 weeks

immune system
increased T cell derived lymphoma incidence ( J:88120 )
• mice develop T cell malignancies starting at 13-15 weeks

hematopoietic system
increased T cell derived lymphoma incidence ( J:88120 )
• mice develop T cell malignancies starting at 13-15 weeks




Genotype
MGI:3036305
tg2
Allelic
Composition		 Tg(Lck)4220Rmp/0
Genetic
Background		 involves: C57BL/6J * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
decreased tumor-free survival time ( J:88120 )
• mice develop T cell tumors and die starting at 7 weeks of age with 100% mortality observed by 14 weeks

neoplasm
increased T cell derived lymphoma incidence ( J:88120 )
• mice develop T cell malignancies starting at 7 weeks

endocrine/exocrine glands
increased T cell derived lymphoma incidence ( J:88120 )
• mice develop T cell malignancies starting at 7 weeks

immune system
increased T cell derived lymphoma incidence ( J:88120 )
• mice develop T cell malignancies starting at 7 weeks

hematopoietic system
increased T cell derived lymphoma incidence ( J:88120 )
• mice develop T cell malignancies starting at 7 weeks




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory