All Phenotypes Ddb2<tm1Linn> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ddb2^tm1Linn
targeted mutation 1, Stuart Linn
MGI:3036308

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ddb2^tm1Linn/Ddb2^tm1Linn	involves: 129S/SvEv * C57BL/6	MGI:3036310
ht2	Ddb2^tm1Linn/Ddb2⁺	involves: 129S/SvEv * C57BL/6	MGI:3036311

Allelic Composition	Ddb2^tm1Linn/Ddb2^tm1Linn
Genetic Background	involves: 129S/SvEv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ddb2^tm1Linn mutation (0 available); any Ddb2 mutation (38 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Tumorigenesis analysis and Hisptopathological images

neoplasm

increased incidence of tumors by UV-induction ( J:88125 )

• skin tumorigenesis is enhanced after exposure to UV light but not after exposure to DMBA

• tumors develop earlier, proceed at a greater rate and mice develop more tumors

cellular

decreased cellular sensitivity to ionizing radiation ( J:88125 )

• MEFs are more resistant to killing after UV-irradiation but not after DMBA exposure

growth/size/body

decreased body size ( J:88125 )

• 8 weeks after birth, homozygotes are somewhat smaller

integument

increased sensitivity to skin irradiation ( J:88125 )

• increased incidence of skin tumors after UV-irradiation

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
xeroderma pigmentosum group E		DOID:0110846	OMIM:278740	J:88125

Allelic Composition	Ddb2^tm1Linn/Ddb2⁺
Genetic Background	involves: 129S/SvEv * C57BL/6