Phenotypes associated with this allele

• Allele Symbol: Tg(Bcl2)ACap
• Allele Name: transgene insertion A, Yassemi Capetanaki
• Allele ID: MGI:3036319
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Des^tm1Cap/Des^tm1Cap Tg(Bcl2)ACap/Tg(Bcl2)ACap	involves: 129S7/SvEvBrd * C57BL/6	MGI:3036355

Genotype
MGI:3036355

cx1

• Allelic Composition: Des^tm1Cap/Des^tm1Cap; Tg(Bcl2)ACap/Tg(Bcl2)ACap
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Cardiac fibrosis and calcification seen in Des^tm1Cap/Des^tm1Cap mice is reduced in Des^tm1Cap/Des^tm1Cap Tg(Bcl2)ACap/Tg(Bcl2)ACap and Des^tm1Cap/Des^tm1Cap Tg(Bcl2)BCap/Tg(Bcl2)BCap mice

cardiovascular system

cardiovascular system phenotype ( J:88267 )

N • the progressive calcification and degeneration observed in Des^tm1Cap homozygotes is ameliorated

cardiac interstitial fibrosis ( J:88267 )

• some fibrosis is observed, althought there are fewer and smaller fibrotic lesions than in Des^tm1Cap homozygotes

• more fibrosis than with similar mice carrying the Tg(Bcl2)BCap, which overexpresses higher levels of BCL2

dystrophic cardiac calcinosis ( J:88267 )

• some calcification is observed, although much less than in Des^tm1Cap homozygotes

• more calcification than with similar mice carrying the Tg(Bcl2)BCap, which overexpresses higher levels of BCL2

cellular

cardiac interstitial fibrosis ( J:88267 )

• some fibrosis is observed, althought there are fewer and smaller fibrotic lesions than in Des^tm1Cap homozygotes

• more fibrosis than with similar mice carrying the Tg(Bcl2)BCap, which overexpresses higher levels of BCL2