Phenotypes associated with this allele

• Allele Symbol: Tg(Bcl2)BCap
• Allele Name: transgene insertion B, Yassemi Capetanaki
• Allele ID: MGI:3036320
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Des^tm1Cap/Des^tm1Cap Tg(Bcl2)BCap/Tg(Bcl2)BCap	involves: 129S7/SvEvBrd * C57BL/6	MGI:3036356

Genotype
MGI:3036356

cx1

• Allelic Composition: Des^tm1Cap/Des^tm1Cap; Tg(Bcl2)BCap/Tg(Bcl2)BCap
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Cardiac fibrosis and calcification seen in Des^tm1Cap/Des^tm1Cap mice is reduced in Des^tm1Cap/Des^tm1Cap Tg(Bcl2)ACap/Tg(Bcl2)ACap and Des^tm1Cap/Des^tm1Cap Tg(Bcl2)BCap/Tg(Bcl2)BCap mice

cardiovascular system

cardiovascular system phenotype ( J:88267 )

N • the progressive calcification and degeneration observed in Des^tm1Cap homozygotes is ameliorated

abnormal myocardial fiber morphology ( J:88267 )

• although cadiomyocytes show a significant improvement from the damage seen in Des^tm1Cap homozygotes, some cardiomyocytes exhibit a loss of mitochondria alignment

cardiac interstitial fibrosis ( J:88267 )

• some fibrosis is observed, although there are fewer and smaller fibrotic lesions than in both Des^tm1Cap homozygotes and Des^tm1Cap homozygotes carrying Tg(Bcl2)ACap

dystrophic cardiac calcinosis ( J:88267 )

• some calcification is observed, althogh less than in both Des^tm1Cap homozygotes and Des^tm1Cap homozygotes carrying Tg(Bcl2)ACap

muscle

abnormal myocardial fiber morphology ( J:88267 )

• although cadiomyocytes show a significant improvement from the damage seen in Des^tm1Cap homozygotes, some cardiomyocytes exhibit a loss of mitochondria alignment

cellular

cardiac interstitial fibrosis ( J:88267 )

• some fibrosis is observed, although there are fewer and smaller fibrotic lesions than in both Des^tm1Cap homozygotes and Des^tm1Cap homozygotes carrying Tg(Bcl2)ACap