Phenotypes associated with this allele

• Allele Symbol: Dll3^pu-J
• Allele Name: pudgy Jackson
• Allele ID: MGI:3036558
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dll3^pu-J/Dll3^pu-J	STOCK Tg(Pfkl)224Yg/J-Dll3^pu-J/GrsrJ	MGI:3051419

Genotype
MGI:3051419

hm1

• Allelic Composition: Dll3^pu-J/Dll3^pu-J
• Genetic Background: STOCK Tg(Pfkl)224Yg/J-Dll3^pu-J/GrsrJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

hindlimb paralysis ( J:88762 )

• affects some homozygous mutant mice

growth/size/body

decreased body length ( J:88762 )

• due to shortened spine

hearing/vestibular/ear

hearing/vestibular/ear phenotype ( J:88762 )

N • three homozygotes and one heterozygote had normal hearing as assessed by acoustic brainstem response (ABR)

limbs/digits/tail

abnormal caudal vertebrae morphology ( J:88762 )

• tail vertebrae exhibit extreme variation in size and shape and irregular fusion

kinked tail ( J:88762 )

reproductive system

abnormal parturition ( J:88762 )

♀ • some homozygous females die giving birth

decreased litter size ( J:88762 )

• homozygous matings produce small litters

skeleton

splayed ribs ( J:88762 )

abnormal vertebrae morphology ( J:88762 )

• although at 5 months of age, growth plates, intervertebral discs, mature bone and marrow appear histologically normal, at 11 months disc, cartilage, bone and marrow occur in a disorganized agglomeration, while in some animals growth plates remain normal in appearance

abnormal caudal vertebrae morphology ( J:88762 )

• tail vertebrae exhibit extreme variation in size and shape and irregular fusion

abnormal thoracic vertebrae morphology ( J:88762 )

• thoracic vertebrae are compressed, misaligned and misshapen

abnormal cervical vertebrae morphology ( J:88762 )

• cervical vertebrae are compressed, misaligned and misshapen

abnormal lumbar vertebrae morphology ( J:88762 )

• lumbar vertebrae are compressed, misaligned and misshapen; however, lower lumbar and sacral vertebrae appear normal

vertebral compression ( J:88762 )

• vertebral compressions are observed in the cervical, thoracic and lumbar regions

decreased compact bone thickness ( J:88762 )

• long bones have very thin cortical shells

abnormal trabecular bone morphology ( J:88762 )

• few trabeculae are visible on 5X magnified X-ray images of long bones

vision/eye

vision/eye phenotype ( J:88762 )

N • eyes of 3 homozygous mutants examined ophthalmoscopically appeared normal