Analysis Tools
mortality/aging
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• mice die in utero between E10.5 and E11.5
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growth/size/body
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• growth retardation, especially in the head region
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cardiovascular system
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• tree-like vascular networks fail to form in the embryonic brain and instead, mutants exhibit plexus-like vascular networks
• vessels in the brain periphery either do not develop or degenerate
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• formation of the major veins, including anterior cardinal vein, is severely impaired
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• impaired vascular remodeling in the brain and yolk sac
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• major trunk veins were not formed
• para-aortic splanchnopleural explants are impaired in the formation of a vascular network when co-cultured with OP9 stromal cells
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• often seen in mutants
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• seen in many mutants
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embryo
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• growth retardation, especially in the head region
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• often show impaired closure of the neural tube
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• somite arrangement is slightly irregular
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• the gap between adjacent somites is slightly narrower
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• although the honeycomb-like vascular plexus of the yolk sac forms normally at E8.5, it remains unchanged at E10.5, indicating absence of vascular remodeling
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homeostasis/metabolism
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• often seen in mutants
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nervous system
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• tree-like vascular networks fail to form in the embryonic brain and instead, mutants exhibit plexus-like vascular networks
• vessels in the brain periphery either do not develop or degenerate
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• seen in many mutants
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• often show impaired closure of the neural tube
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integument
