All Phenotypes Elk4<tm1Rtr> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Elk4^tm1Rtr
targeted mutation 1, Richard Treisman
MGI:3036598

Summary

6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Elk4^tm1Rtr/Elk4^tm1Rtr	either: (involves: 129/Sv) or (involves: 129/Sv * C57BL/6)	MGI:3036847
cx2	Elk1^tm1Nor/Y Elk4^tm1Rtr/Elk4^tm1Rtr	involves: 129P2/OlaHsd	MGI:5790493
cx3	Elk1^tm1Nor/Elk1^tm1Nor Elk4^tm1Rtr/Elk4^tm1Rtr	involves: 129P2/OlaHsd	MGI:5790494
cx4	Elk4^tm1Rtr/Elk4^tm1Rtr Tg(TcraTcrb)425Cbn/?	involves: 129/Sv * C57BL/6	MGI:3036848
cx5	Elk4^tm1Rtr/Elk4^tm1Rtr Tg(TcrLCMV)327Sdz/?	involves: 129/Sv * C57BL/6 * DBA/2	MGI:3851780
cx6	Elk4^tm1Rtr/Elk4^tm1Rtr Tg(TcraH-Y,TcrbH-Y)71Vbo/?	involves: 129/Sv * C57BL/6 * DBA/2J	MGI:3851783

Allelic Composition	Elk4^tm1Rtr/Elk4^tm1Rtr
Genetic Background	either: (involves: 129/Sv) or (involves: 129/Sv * C57BL/6)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Elk4^tm1Rtr mutation (0 available); any Elk4 mutation (17 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal T cell selection ( J:88515 )

• abnormal thymocyte selection and/or differentiation

abnormal positive T cell selection ( J:88515 )

• T cell autonomous defect affecting positive, but not negative, selection

decreased T cell number ( J:88515 )

• reduced number of peripheral T cells

decreased thymocyte number ( J:88515 )

• 50% reduction in the proportion of TCR^hi thymocytes

decreased CD4-positive, alpha-beta T cell number ( J:88515 )

• 50% reduction in the proportion of single-positive CD4⁺thymocytes

decreased CD8-positive, alpha-beta T cell number ( J:88515 )

• reduction in the proportion of single-positive CD8⁺ thymocytes

decreased single-positive T cell number ( J:88515 )

immune system

abnormal T cell selection ( J:88515 )

• abnormal thymocyte selection and/or differentiation

abnormal positive T cell selection ( J:88515 )

• T cell autonomous defect affecting positive, but not negative, selection

decreased T cell number ( J:88515 )

• reduced number of peripheral T cells

decreased thymocyte number ( J:88515 )

• 50% reduction in the proportion of TCR^hi thymocytes

decreased CD4-positive, alpha-beta T cell number ( J:88515 )

• 50% reduction in the proportion of single-positive CD4⁺thymocytes

decreased CD8-positive, alpha-beta T cell number ( J:88515 )

• reduction in the proportion of single-positive CD8⁺ thymocytes

decreased single-positive T cell number ( J:88515 )

endocrine/exocrine glands

decreased thymocyte number ( J:88515 )

• 50% reduction in the proportion of TCR^hi thymocytes

Allelic Composition	Elk1^tm1Nor/Y Elk4^tm1Rtr/Elk4^tm1Rtr
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Elk1^tm1Nor mutation (0 available); any Elk1 mutation (8 available)
Elk4^tm1Rtr mutation (0 available); any Elk4 mutation (17 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

vision/eye phenotype ( J:221521 )

N	• adult mice show no apparent changes in retinal arterial shapes, lengths and widths nor in retinal layering and layer thickness relative to wild-type controls • no retinal neovascularization is observed

Allelic Composition	Elk1^tm1Nor/Elk1^tm1Nor Elk4^tm1Rtr/Elk4^tm1Rtr
Genetic Background	involves: 129P2/OlaHsd

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

vision/eye phenotype ( J:221521 )

N	• adult mice show no apparent changes in retinal arterial shapes, lengths and widths nor in retinal layering and layer thickness relative to wild-type controls • no retinal neovascularization is observed

Allelic Composition	Elk4^tm1Rtr/Elk4^tm1Rtr Tg(TcraTcrb)425Cbn/?
Genetic Background	involves: 129/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Elk4^tm1Rtr mutation (0 available); any Elk4 mutation (17 available)
Tg(TcraTcrb)425Cbn mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal positive T cell selection ( J:88515 )

• CD4 thymocyte positive selection is impaired; mutants generate about 75% fewer CD4⁺ single-positive thymocytes than wild-type

decreased CD4-positive, alpha-beta T cell number ( J:88515 )

• mutants generate about 75% fewer CD4⁺ single-positive thymocytes than wild-type

abnormal splenic cell ratio ( J:88515 )

• decrease in splenic CD4:CD8 ratio

immune system

abnormal positive T cell selection ( J:88515 )

• CD4 thymocyte positive selection is impaired; mutants generate about 75% fewer CD4⁺ single-positive thymocytes than wild-type

decreased CD4-positive, alpha-beta T cell number ( J:88515 )

• mutants generate about 75% fewer CD4⁺ single-positive thymocytes than wild-type

abnormal splenic cell ratio ( J:88515 )

• decrease in splenic CD4:CD8 ratio

Allelic Composition	Elk4^tm1Rtr/Elk4^tm1Rtr Tg(TcrLCMV)327Sdz/?
Genetic Background	involves: 129/Sv * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Elk4^tm1Rtr mutation (0 available); any Elk4 mutation (17 available)
Tg(TcrLCMV)327Sdz mutation (8 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal positive T cell selection ( J:88515 )

• CD8 thymocyte positive selection is impaired: the proportion of CD8⁺ single positive thymocytes is reduced by about 75% and gating on TCR^hi cells show almost 90% reduction

decreased CD8-positive, alpha-beta T cell number ( J:88515 )

• the proportion of CD8⁺ single positive thymocytes is reduced by about 75% and gating on TCR^hi cells show almost 90% reduction

immune system

abnormal positive T cell selection ( J:88515 )

• CD8 thymocyte positive selection is impaired: the proportion of CD8⁺ single positive thymocytes is reduced by about 75% and gating on TCR^hi cells show almost 90% reduction

decreased CD8-positive, alpha-beta T cell number ( J:88515 )

• the proportion of CD8⁺ single positive thymocytes is reduced by about 75% and gating on TCR^hi cells show almost 90% reduction

Allelic Composition	Elk4^tm1Rtr/Elk4^tm1Rtr Tg(TcraH-Y,TcrbH-Y)71Vbo/?
Genetic Background	involves: 129/Sv * C57BL/6 * DBA/2J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Elk4^tm1Rtr mutation (0 available); any Elk4 mutation (17 available)
Tg(TcraH-Y,TcrbH-Y)71Vbo mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal positive T cell selection ( J:88515 )

• CD8 thymocyte positive selection is impaired; females show an approximate 80% reduction in CD8⁺ single-positive thymocyte numbers and 60% reduction in the proportion of TCR^hi cells

decreased CD8-positive, alpha-beta T cell number ( J:88515 )

• females show an approximate 80% reduction in CD8⁺ single-positive thymocyte numbers and 60% reduction in the proportion of TCR^hi cells

immune system

abnormal positive T cell selection ( J:88515 )

• CD8 thymocyte positive selection is impaired; females show an approximate 80% reduction in CD8⁺ single-positive thymocyte numbers and 60% reduction in the proportion of TCR^hi cells

decreased CD8-positive, alpha-beta T cell number ( J:88515 )

• females show an approximate 80% reduction in CD8⁺ single-positive thymocyte numbers and 60% reduction in the proportion of TCR^hi cells

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