Phenotypes associated with this allele

• Allele Symbol: Gipr^tm1Thor
• Allele Name: targeted mutation 1, Bernard Thorens
• Allele ID: MGI:3036704
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gipr^tm1Thor/Gipr^tm1Thor	involves: 129P2/OlaHsd * C57BL/6	MGI:3036841
cx2	Gipr^tm1Thor/Gipr^tm1Thor Glp1r^tm1Ddr/Glp1r^tm1Ddr	involves: 129/Sv * 129P2/OlaHsd * C57BL/6	MGI:3036843

Genotype
MGI:3036841

hm1

• Allelic Composition: Gipr^tm1Thor/Gipr^tm1Thor
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

abnormal pancreas secretion ( J:88159 )

• no decrease in first phase of insulin secretion

• blunted second phase of insulin secretion

homeostasis/metabolism

increased circulating glucose level ( J:88159 )

• in response to oral glucose consumption observed in both males and females relative to wild-type controls

• observed in female mice, but not male mice, following intraperitoneal glucose injection

decreased circulating insulin level ( J:88159 )

• reduced insulin response to oral glucose consumption observed in both males and females relative to wild-type controls

• following intraperitoneal glucose injection, the first phase insulin secretion was normal, however insulin levels were reduced 30 minutes later

impaired glucose tolerance ( J:88159 )

• observed in both male and female mice after oral glucose consumption

• observed in female mice, but not male mice, after intraperitoneal glucose injection

Genotype
MGI:3036843

cx2

• Allelic Composition: Gipr^tm1Thor/Gipr^tm1Thor; Glp1r^tm1Ddr/Glp1r^tm1Ddr
• Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

endocrine/exocrine glands

abnormal pancreas secretion ( J:88159 )

• blunted first phase of insulin secretion

• no decrease in second phase of insulin secretion

• beta-cell autonomous defect in stimulated insulin secretion

homeostasis/metabolism

increased circulating glucose level ( J:88159 )

• observed in both males and females relative to wild-type controls following oral glucose consumption

• observed in female mice, but not male mice, following intraperitoneal glucose injection

decreased circulating insulin level ( J:88159 )

• reduced insulin response to oral glucose consumption observed in both males and females relative to wild-type controls as well as to single knockout mice

• absence of first phase insulin secretion

impaired glucose tolerance ( J:88159 )

• observed in both male and female mice, following oral glucose consumption, however females showed a greater impairment than males

• observed in female mice, but not male mice, after intraperitoneal glucose injection

• greater intolerance relative to single knockout mice

• normal insulin sensitivity indicated by euglycemic clamp