Phenotypes associated with this allele

• Allele Symbol: Ptafr^tm1Tksh
• Allele Name: targeted mutation 1, Takao Shimizu
• Allele ID: MGI:3036770
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ptafr^tm1Tksh/Ptafr^tm1Tksh	C57BL/6-Ptafr^tm1Tksh	MGI:3038300
hm2	Ptafr^tm1Tksh/Ptafr^tm1Tksh	involves: 129P2/OlaHsd * C57BL/6	MGI:3038289

Genotype
MGI:3038300

hm1

• Allelic Composition: Ptafr^tm1Tksh/Ptafr^tm1Tksh
• Genetic Background: C57BL/6-Ptafr^tm1Tksh

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased susceptibility to bacterial infection ( J:88589 )

• improved host defense against Streptococcus pneumoniae; mutants exhibit delayed and reduced mortality, diminished outgrowth of pneumococci in lungs, reduced dissemination of infection and reduced pulmonary inflammation

Genotype
MGI:3038289

hm2

• Allelic Composition: Ptafr^tm1Tksh/Ptafr^tm1Tksh
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

immune system

increased susceptibility to type I hypersensitivity reaction ( J:88505 )

• homozygous mutants have a marked reduction in systemic anaphylactic symptoms when challenged with ovalbumin (OVA)

• compared to controls, homozygous mice did not develop anaphylactic hypotension, anaphylactic tachycardia followed by bradycardia nor do they develop any anaphylaxis dependent changes in the lungs or suffer lethal affects in response to antigen challenge

• homozygous mutants do respond normally to endotoxins and develop endotoixc shock at the same level as controls

decreased inflammatory response ( J:87866 )

• inflammatory response to S. venezuelensis worm infection is lower at 7 days after infection as indicated by lower numbers of eosinophils and globlet cells in tissue and diminished cytokine production, with a reduction in the production of Th2 cytokines (IL-4, IL-5, and IL-10) in the small intestine and by specific antigen-stimulated spleen or MLN cells

increased susceptibility to parasitic infection ( J:87866 )

• while the fecundity of the worm, Strongyloides venezuelensis, is decreased in mutant mice, overall elimination is delayed

cardiovascular system

cardiovascular system phenotype ( J:88505 )

N • no changes are found in blood cell populations, differential leukocyte counts, or serum biochemical parameters

N • no significant differences in baseline mean arterial pressure or heart rate are found

reproductive system

reproductive system phenotype ( J:88505 )

N • homozygous mutants are fertile and produce healthy litters of normal size

nervous system

nervous system phenotype ( J:88505 )

N • no malformations of the brain are found in homozygotes