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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Celf4Ff
frequent flyer
MGI:3037035
Summary 8 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Celf4Ff/Celf4Ff involves: 129S1/Sv * C57BL/6J MGI:3721397
hm2
 		Celf4Ff/Celf4Ff involves: A/J * C57BL/6J MGI:3721395
hm3
 		Celf4Ff/Celf4Ff involves: BALB/cByJ * C57BL/6J MGI:3721396
hm4
 		Celf4Ff/Celf4Ff involves: C3H/HeJ * C57BL/6J MGI:3721392
hm5
 		Celf4Ff/Celf4Ff involves: C57BL/6J MGI:3721391
hm6
 		Celf4Ff/Celf4Ff involves: C57BL/6J * EL/EFrkJ MGI:3721393
hm7
 		Celf4Ff/Celf4Ff involves: C57BL/6J * FVB/NJ MGI:3721394
ht8
 		Celf4Ff/Celf4+ involves: C57BL/6J MGI:3721390


Genotype
MGI:3721397
hm1
Allelic
Composition		 Celf4Ff/Celf4Ff
Genetic
Background		 involves: 129S1/Sv * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Celf4Ff mutation (1 available); any Celf4 mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:123744 )
• Background Sensitivity: only 8.2% of mice survive until 4 weeks on a 129S1, C57BL/6 mixed background




Genotype
MGI:3721395
hm2
Allelic
Composition		 Celf4Ff/Celf4Ff
Genetic
Background		 involves: A/J * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Celf4Ff mutation (1 available); any Celf4 mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:123744 )
• Background Sensitivity: only 5.8% of mice survive until 4 weeks on a A/J, C57BL/6 mixed background




Genotype
MGI:3721396
hm3
Allelic
Composition		 Celf4Ff/Celf4Ff
Genetic
Background		 involves: BALB/cByJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Celf4Ff mutation (1 available); any Celf4 mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:123744 )
• only 7.4% of mice survive until 4 weeks on a BALB/cByJ, C57BL/6 mixed background




Genotype
MGI:3721392
hm4
Allelic
Composition		 Celf4Ff/Celf4Ff
Genetic
Background		 involves: C3H/HeJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Celf4Ff mutation (1 available); any Celf4 mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:123744 )
• Background Sensitivity: only 2.2% of mice survive until 4 weeks on a C3H/HeJ, C57BL/6 mixed background




Genotype
MGI:3721391
hm5
Allelic
Composition		 Celf4Ff/Celf4Ff
Genetic
Background		 involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Celf4Ff mutation (1 available); any Celf4 mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:123744 )
• Background Sensitivity: only 1.1% of mice survive until 4 weeks on a C57BL/6 background
neonatal lethality, incomplete penetrance ( J:123744 )
• most mice die within the first day of birth

behavior/neurological
tonic-clonic seizures ( J:123744 )
• mice that survive for more than 6 months exhibit limbic and tonic-clonic seizures

growth/size/body
decreased body size ( J:123744 )
• mice that survive for more than 6 months are smaller in size compared to wild-type mice

nervous system
tonic-clonic seizures ( J:123744 )
• mice that survive for more than 6 months exhibit limbic and tonic-clonic seizures




Genotype
MGI:3721393
hm6
Allelic
Composition		 Celf4Ff/Celf4Ff
Genetic
Background		 involves: C57BL/6J * EL/EFrkJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Celf4Ff mutation (1 available); any Celf4 mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:123744 )
• only 3.6% of mice survive until 4 weeks on a EL/EFrkJ, C57BL/6 mixed background




Genotype
MGI:3721394
hm7
Allelic
Composition		 Celf4Ff/Celf4Ff
Genetic
Background		 involves: C57BL/6J * FVB/NJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Celf4Ff mutation (1 available); any Celf4 mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:123744 )
• only 5.6% of mice survive until 4 weeks on a FVB/NJ, C57BL/6 mixed background

behavior/neurological
absence seizures ( J:123744 )
• Background Sensitivity: mice experience exhibit spike-wave discharges on a FVB/NJ, C57BL/6 background but not a 129S1, C57BL/6 mixed background

nervous system
absence seizures ( J:123744 )
• Background Sensitivity: mice experience exhibit spike-wave discharges on a FVB/NJ, C57BL/6 background but not a 129S1, C57BL/6 mixed background




Genotype
MGI:3721390
ht8
Allelic
Composition		 Celf4Ff/Celf4+
Genetic
Background		 involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Celf4Ff mutation (1 available); any Celf4 mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Celf4Ff/Brunol4+ mice exhibit seizures

behavior/neurological
hyperactivity ( J:123744 )
• mice are slightly hyperactive
seizures ( J:123744 )
• at 3 months of age, mice exhibit seizures
• seizures range in severity from milder muscle twitching in the face and neck, forelimb clonus, and salivation to rearing and falling, myoclonic jerks, and arching of the back and tail
• seizures are often followed by running-bouncing phase with occasional tonic-clonic hinbdlimb extension
• incidence of seizures decrease with age
abnormal seizure response to electrical stimulation ( J:123744 )
• at 7 weeks, mice have a reduce threshold to electroconvulsive seizure

growth/size/body
increased body weight ( J:123744 )
• by week 35 mice are 10% heavier than wild-type mice
increased susceptibility to weight gain ( J:123744 )
• mice exhibit a late-onset weight gain resulting in 10% heavier weight compared to wild-type mice
decreased body size ( J:123744 )
• mice are slightly smaller at weaning

nervous system
seizures ( J:123744 )
• at 3 months of age, mice exhibit seizures
• seizures range in severity from milder muscle twitching in the face and neck, forelimb clonus, and salivation to rearing and falling, myoclonic jerks, and arching of the back and tail
• seizures are often followed by running-bouncing phase with occasional tonic-clonic hinbdlimb extension
• incidence of seizures decrease with age
abnormal seizure response to electrical stimulation ( J:123744 )
• at 7 weeks, mice have a reduce threshold to electroconvulsive seizure




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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory