About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ighmtm1Fbb
targeted mutation 1, Frank Brombacher
MGI:3037070
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ighmtm1Fbb/Ighmtm1Fbb involves: BALB/cJ MGI:3037082


Genotype
MGI:3037082
hm1
Allelic
Composition		 Ighmtm1Fbb/Ighmtm1Fbb
Genetic
Background		 involves: BALB/cJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ighmtm1Fbb mutation (0 available); any Ighm mutation (56 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:57600 )
N
• normal B cell development and maturation, the expression of IgD (Igh-5) largely compensates for the lack of IgM (Igh-6)
increased susceptibility to Riboviria infection ( J:57600 )
• while mice survived infection with vesicular stomatitis virus by developing neutralizing immunoglobulins, the immune response was delayed relative to wild-type




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory