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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Prkcatm1Jmk
targeted mutation 1, Jeffery D Molkentin
MGI:3037088
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Prkcatm1Jmk/Prkcatm1Jmk involves: 129 MGI:3851898
cx2
 		Csrp3tm1Crni/Csrp3tm1Crni
Prkcatm1Jmk/Prkcatm1Jmk 		involves: 129 MGI:3037158


Genotype
MGI:3851898
hm1
Allelic
Composition		 Prkcatm1Jmk/Prkcatm1Jmk
Genetic
Background		 involves: 129
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prkcatm1Jmk mutation (1 available); any Prkca mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
cardiovascular system phenotype ( J:88510 , J:132098 )
N
• normal baseline blood pressure and heart rate (J:88510)
• heart weight/body weight ratios are not altered in mutants at 16 weeks after myocardial infarction (MI) but ratio is significantly higher in wild-type at this point (J:132098)
abnormal myocardium layer morphology ( J:132098 )
• mutant mice show equivalent infarcted area/area at risk ratio to wild-type after myocardial infarction
abnormal cardiac muscle contractility ( J:132098 )
• after myocardial infarction (MI), ventricular function is maintained in mutants compared to wild-type; fractional shortening is rescued at most time points evaluated after MI
decreased response of heart to induced stress ( J:88510 )
• mice were less susceptible to TAC-induced pressure overload heart failure than wild-type controls

muscle
abnormal myocardium layer morphology ( J:132098 )
• mutant mice show equivalent infarcted area/area at risk ratio to wild-type after myocardial infarction
abnormal cardiac muscle contractility ( J:132098 )
• after myocardial infarction (MI), ventricular function is maintained in mutants compared to wild-type; fractional shortening is rescued at most time points evaluated after MI

homeostasis/metabolism
decreased response of heart to induced stress ( J:88510 )
• mice were less susceptible to TAC-induced pressure overload heart failure than wild-type controls




Genotype
MGI:3037158
cx2
Allelic
Composition		 Csrp3tm1Crni/Csrp3tm1Crni
Prkcatm1Jmk/Prkcatm1Jmk
Genetic
Background		 involves: 129
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Csrp3tm1Crni mutation (0 available); any Csrp3 mutation (15 available)
Prkcatm1Jmk mutation (1 available); any Prkca mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
cardiovascular system phenotype ( J:88510 )
N
• partial rescue of the dilated cardiomyopathic phenotype observed in Csrp3tm1Crni homozygotes
• normal ventricular performance
dilated heart left ventricle ( J:88510 )
• relative to wild-type
• observed dilation was reduced relative to Csrp3tm1Crni homozygotes




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/17/2024
MGI 6.24 		The Jackson Laboratory