Phenotypes associated with this allele

• Allele Symbol: Prkca^tm1Jmk
• Allele Name: targeted mutation 1, Jeffery D Molkentin
• Allele ID: MGI:3037088
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Prkca^tm1Jmk/Prkca^tm1Jmk	involves: 129	MGI:3851898
cx2	Csrp3^tm1Crni/Csrp3^tm1Crni Prkca^tm1Jmk/Prkca^tm1Jmk	involves: 129	MGI:3037158

Genotype
MGI:3851898

hm1

• Allelic Composition: Prkca^tm1Jmk/Prkca^tm1Jmk
• Genetic Background: involves: 129

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:88510 , J:132098 )

N • normal baseline blood pressure and heart rate (J:88510)

N • heart weight/body weight ratios are not altered in mutants at 16 weeks after myocardial infarction (MI) but ratio is significantly higher in wild-type at this point (J:132098)

abnormal myocardium layer morphology ( J:132098 )

• mutant mice show equivalent infarcted area/area at risk ratio to wild-type after myocardial infarction

abnormal cardiac muscle contractility ( J:132098 )

• after myocardial infarction (MI), ventricular function is maintained in mutants compared to wild-type; fractional shortening is rescued at most time points evaluated after MI

decreased response of heart to induced stress ( J:88510 )

• mice were less susceptible to TAC-induced pressure overload heart failure than wild-type controls

muscle

abnormal myocardium layer morphology ( J:132098 )

• mutant mice show equivalent infarcted area/area at risk ratio to wild-type after myocardial infarction

abnormal cardiac muscle contractility ( J:132098 )

• after myocardial infarction (MI), ventricular function is maintained in mutants compared to wild-type; fractional shortening is rescued at most time points evaluated after MI

homeostasis/metabolism

decreased response of heart to induced stress ( J:88510 )

• mice were less susceptible to TAC-induced pressure overload heart failure than wild-type controls

Genotype
MGI:3037158

cx2

• Allelic Composition: Csrp3^tm1Crni/Csrp3^tm1Crni; Prkca^tm1Jmk/Prkca^tm1Jmk
• Genetic Background: involves: 129

cardiovascular system

cardiovascular system phenotype ( J:88510 )

N • partial rescue of the dilated cardiomyopathic phenotype observed in Csrp3^tm1Crni homozygotes

N • normal ventricular performance

dilated heart left ventricle ( J:88510 )

• relative to wild-type

• observed dilation was reduced relative to Csrp3^tm1Crni homozygotes