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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tia1tm1Andp
targeted mutation 1, Paul Anderson
MGI:3037091
Summary 3 genotypes


Genotype
MGI:3037331
hm1
Allelic
Composition		 Tia1tm1Andp/Tia1tm1Andp
Genetic
Background		 B6.Cg-Tia1tm1Andp
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tia1tm1Andp mutation (2 available); any Tia1 mutation (68 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
autoimmune arthritis ( J:88443 )
• homozygotes develop mild arthritis
• swollen joints display minimal display inflammatory pannus and rare bony erosions

skeleton
autoimmune arthritis ( J:88443 )
• homozygotes develop mild arthritis
• swollen joints display minimal display inflammatory pannus and rare bony erosions




Genotype
MGI:3037319
hm2
Allelic
Composition		 Tia1tm1Andp/Tia1tm1Andp
Genetic
Background		 C.129S2-Tia1tm1Andp
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tia1tm1Andp mutation (2 available); any Tia1 mutation (68 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, incomplete penetrance ( J:88770 )
• approximately 50% of homozygotes die between E16.5 and 3 weeks
• survivors appear normal and live up to 2 years

hematopoietic system
hematopoietic system phenotype ( J:88770 )
N
• major hematopoietic lineages are in normal proportions
abnormal macrophage physiology ( J:88770 )
• in macrophages from homozygotes lipopolysaccharide-induced expression of TNF- alpha and IL-6 is significantly increased

immune system
immune system phenotype ( J:88770 )
N
• the thymus is normal
abnormal macrophage physiology ( J:88770 )
• in macrophages from homozygotes lipopolysaccharide-induced expression of TNF- alpha and IL-6 is significantly increased
increased susceptibility to endotoxin shock ( J:88770 )
• mutants are more susceptible to lipopolysaccharide-induced endotoxin shock




Genotype
MGI:3037328
cx3
Allelic
Composition		 Tia1tm1Andp/Tia1tm1Andp
Zfp36tm1Pjb/Zfp36tm1Pjb
Genetic
Background		 B6.Cg-Tia1tm1Andp Zfp36tm1Pjb
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tia1tm1Andp mutation (2 available); any Tia1 mutation (68 available)
Zfp36tm1Pjb mutation (1 available); any Zfp36 mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
postnatal growth retardation ( J:88443 )
• double homozygotes are small at birth and grow slowly

hematopoietic system
increased neutrophil cell number ( J:88443 )
• significant increases in neutrophils are found in the bone marrow and peripheral blood
abnormal macrophage physiology ( J:88443 )
• in macrophages from double homozygotes lipopolysaccharide-induced expression of TNF- alpha is significantly increased

immune system
increased neutrophil cell number ( J:88443 )
• significant increases in neutrophils are found in the bone marrow and peripheral blood
abnormal macrophage physiology ( J:88443 )
• in macrophages from double homozygotes lipopolysaccharide-induced expression of TNF- alpha is significantly increased
autoimmune arthritis ( J:88443 )
• double homozygotes develop arthritis that is more severe than that seen in either single homozygote
• finger joints from double homozygotes display inflammatory pannus and bony erosions

skeleton
autoimmune arthritis ( J:88443 )
• double homozygotes develop arthritis that is more severe than that seen in either single homozygote
• finger joints from double homozygotes display inflammatory pannus and bony erosions




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/09/2024
MGI 6.24 		The Jackson Laboratory