Phenotypes associated with this allele

• Allele Symbol: Pou2f2^tm1Lmc
• Allele Name: targeted mutation 1, Lynn M Corcoran
• Allele ID: MGI:3037094
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pou2f2^tm1Lmc/Pou2f2^tm1Lmc	involves: C57BL/6	MGI:3037268

Genotype
MGI:3037268

hm1

• Allelic Composition: Pou2f2^tm1Lmc/Pou2f2^tm1Lmc
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:88240 )

• homozygous mice die shortly after birth

hematopoietic system

arrested B cell differentiation ( J:88240 )

• in adult Rag-1 deficient mice in which the immune system has been reconstituted with fetal liver stem cells from mutants peripheral B cells appear mature but behave as immature B cells in response to B cell receptor signaling

decreased B cell number ( J:88240 )

• in adult Rag-1 deficient mice in which the immune system has been reconstituted with fetal liver stem cells from mutants the proportion of B cells is significantly reduced

decreased B-1 B cell number ( J:88240 )

• these mice also lack peritoneal B-1 cells

decreased immunoglobulin level ( J:88240 )

• in adult Rag-1 deficient mice in which the immune system has been reconstituted with fetal liver stem cells from mutants an 8 - 10 fold reduction in immunoglobulin concentrations is seen

immune system

arrested B cell differentiation ( J:88240 )

• in adult Rag-1 deficient mice in which the immune system has been reconstituted with fetal liver stem cells from mutants peripheral B cells appear mature but behave as immature B cells in response to B cell receptor signaling

decreased B cell number ( J:88240 )

• in adult Rag-1 deficient mice in which the immune system has been reconstituted with fetal liver stem cells from mutants the proportion of B cells is significantly reduced

decreased B-1 B cell number ( J:88240 )

• these mice also lack peritoneal B-1 cells

decreased immunoglobulin level ( J:88240 )

• in adult Rag-1 deficient mice in which the immune system has been reconstituted with fetal liver stem cells from mutants an 8 - 10 fold reduction in immunoglobulin concentrations is seen