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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Pou2f2tm1Lmc
targeted mutation 1, Lynn M Corcoran
MGI:3037094
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Pou2f2tm1Lmc/Pou2f2tm1Lmc involves: C57BL/6 MGI:3037268


Genotype
MGI:3037268
hm1
Allelic
Composition		 Pou2f2tm1Lmc/Pou2f2tm1Lmc
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pou2f2tm1Lmc mutation (0 available); any Pou2f2 mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, complete penetrance ( J:88240 )
• homozygous mice die shortly after birth

hematopoietic system
arrested B cell differentiation ( J:88240 )
• in adult Rag-1 deficient mice in which the immune system has been reconstituted with fetal liver stem cells from mutants peripheral B cells appear mature but behave as immature B cells in response to B cell receptor signaling
decreased B cell number ( J:88240 )
• in adult Rag-1 deficient mice in which the immune system has been reconstituted with fetal liver stem cells from mutants the proportion of B cells is significantly reduced
decreased B-1 B cell number ( J:88240 )
• these mice also lack peritoneal B-1 cells
decreased immunoglobulin level ( J:88240 )
• in adult Rag-1 deficient mice in which the immune system has been reconstituted with fetal liver stem cells from mutants an 8 - 10 fold reduction in immunoglobulin concentrations is seen

immune system
arrested B cell differentiation ( J:88240 )
• in adult Rag-1 deficient mice in which the immune system has been reconstituted with fetal liver stem cells from mutants peripheral B cells appear mature but behave as immature B cells in response to B cell receptor signaling
decreased B cell number ( J:88240 )
• in adult Rag-1 deficient mice in which the immune system has been reconstituted with fetal liver stem cells from mutants the proportion of B cells is significantly reduced
decreased B-1 B cell number ( J:88240 )
• these mice also lack peritoneal B-1 cells
decreased immunoglobulin level ( J:88240 )
• in adult Rag-1 deficient mice in which the immune system has been reconstituted with fetal liver stem cells from mutants an 8 - 10 fold reduction in immunoglobulin concentrations is seen




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory