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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gata1tm6Sho
targeted mutation 6, Stuart Orkin
MGI:3037864
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Gata1tm6Sho/Gata1tm6Sho C.129S1-Gata1tm6Sho MGI:5316007
hm2
 		Gata1tm6Sho/Gata1tm6Sho involves: 129S1/Sv MGI:3037966
hm3
 		Gata1tm6Sho/Gata1tm6Sho involves: 129S1/Sv * BALB/c MGI:4847667
ot4
 		Gata1tm6Sho/Y involves: 129S1/Sv MGI:3037970


Genotype
MGI:5316007
hm1
Allelic
Composition		 Gata1tm6Sho/Gata1tm6Sho
Genetic
Background		 C.129S1-Gata1tm6Sho
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata1tm6Sho mutation (4 available); any Gata1 mutation (45 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
autoimmune response ( J:182213 )
• mutants exhibit impaired epidermal and dermal thickening and collagen deposition in OVA-sensitized skin (to induce allergic skin inflammation) compared to wild-type mice
• eosinophils are not detectable in skin of EC-sensitized mutants with OVA, however dermal infiltration by CD4+ cells is similar to wild-type mice and systemic immune response to EC sensitization with OVA is comparable to wild-type controls

integument
abnormal skin physiology ( J:182213 )
• mutants exhibit impaired epidermal and dermal thickening and collagen deposition in OVA-sensitized skin (to induce allergic skin inflammation) compared to wild-type mice




Genotype
MGI:3037966
hm2
Allelic
Composition		 Gata1tm6Sho/Gata1tm6Sho
Genetic
Background		 involves: 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata1tm6Sho mutation (4 available); any Gata1 mutation (45 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
hematopoietic system phenotype ( J:88711 )
N
• all other hematopoietic lineages are normal
• mutants are viable, fertile and have no gross abnormalities
decreased eosinophil cell number ( J:88711 )
• eosinophils are absent

immune system
decreased eosinophil cell number ( J:88711 )
• eosinophils are absent




Genotype
MGI:4847667
hm3
Allelic
Composition		 Gata1tm6Sho/Gata1tm6Sho
Genetic
Background		 involves: 129S1/Sv * BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata1tm6Sho mutation (4 available); any Gata1 mutation (45 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
respiratory system
respiratory system phenotype ( J:92849 )
N
• methacholine induced airway hypersensitivity is unaffected
abnormal bronchiole morphology ( J:92849 )
• reduced extracellular matrix deposition in bronchioles after allergen challenge
• also in perivascular regions
abnormal respiratory system physiology ( J:92849 )
• reduced mucus production after Aspergillus fumigatus exposure
• airway smooth muscle proliferation does not occur in response to allergen

hematopoietic system
abnormal leukocyte cell number ( J:115273 )
• impaired recruitment into bronchoalveolar lavage fluid generally
decreased eosinophil cell number ( J:115273 )
• eosinophils are absent in bronchoalveolar lavage fluid after Aspergillus fumigatus exposure
increased neutrophil cell number ( J:115273 )
• three fold increase in airway neutrophilia after Aspergillus fumigatus exposure
decreased lymphocyte cell number ( J:115273 )
• 50% lymphocyte reduction in bronchoalveolar lavage fluid after Aspergillus fumigatus exposure

immune system
abnormal leukocyte cell number ( J:115273 )
• impaired recruitment into bronchoalveolar lavage fluid generally
decreased eosinophil cell number ( J:115273 )
• eosinophils are absent in bronchoalveolar lavage fluid after Aspergillus fumigatus exposure
increased neutrophil cell number ( J:115273 )
• three fold increase in airway neutrophilia after Aspergillus fumigatus exposure
decreased lymphocyte cell number ( J:115273 )
• 50% lymphocyte reduction in bronchoalveolar lavage fluid after Aspergillus fumigatus exposure
decreased circulating interleukin-13 level ( J:115273 )
• after Aspergillus fumigatus exposure
decreased circulating interleukin-4 level ( J:115273 )
• after Aspergillus fumigatus exposure

homeostasis/metabolism
decreased circulating interleukin-13 level ( J:115273 )
• after Aspergillus fumigatus exposure
decreased circulating interleukin-4 level ( J:115273 )
• after Aspergillus fumigatus exposure
abnormal hemostasis ( J:115273 )
• more modest increase in coagulation components after allergen stimulation than seen in controls




Genotype
MGI:3037970
ot4
Allelic
Composition		 Gata1tm6Sho/Y
Genetic
Background		 involves: 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata1tm6Sho mutation (4 available); any Gata1 mutation (45 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
hematopoietic system phenotype ( J:88711 )
N
• mast cell production in the bone marrow is normal
enlarged spleen ( J:88711 )
• modest splenomegaly is seen in males
decreased eosinophil cell number ( J:88711 )
• eosinophils are absent
decreased erythrocyte cell number ( J:88711 )
• erythrocyte number is reduced by 27% in males
decreased hematocrit ( J:88711 )
• hemoglobin level is reduced in proportion with the reduction in erythrocyte number

immune system
enlarged spleen ( J:88711 )
• modest splenomegaly is seen in males
decreased eosinophil cell number ( J:88711 )
• eosinophils are absent

growth/size/body
enlarged spleen ( J:88711 )
• modest splenomegaly is seen in males




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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory