Phenotypes associated with this allele

• Allele Symbol: Egfr^Vel
• Allele Name: velvet
• Allele ID: MGI:3037902
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Egfr^Vel/Egfr^Vel	involves: C57BL/6J	MGI:3037921
ht2	Egfr^Vel/Egfr^+	involves: C57BL/6J	MGI:3037922

Genotype
MGI:3037921

hm1

• Allelic Composition: Egfr^Vel/Egfr^Vel
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:88776 )

• homozygous mutant embryos do not survive past E13.5, putatively due to a placenta defect

• a significant reduction in embryonic viability is first noted at E11.5

embryo

placental labyrinth hypoplasia ( J:88776 )

• at E12.5, homozygous mutant placentas show a significant reduction in cell number relative to wild-type and heterozygous controls

• a number of dead or dying cells are also observed

abnormal trophoblast layer morphology ( J:88776 )

• at E12.5, the labyrinth trophoblast layer appears disorganized

• however, the organization and number of trophoblast giant cells remain relatively normal

Genotype
MGI:3037922

ht2

• Allelic Composition: Egfr^Vel/Egfr⁺
• Genetic Background: involves: C57BL/6J

vision/eye

cornea opacity ( J:88776 )

• the eyes of adult heterozygotes exhibit corneal opacity

microphthalmia ( J:88776 )

• the eyes of adult heterozygotes are often small

abnormal eyelid morphology ( J:88776 )

• excessive secretions are always observed at the edges of adult heterozygous mutant eyelids, possibly due to infection, drying, or trauma

abnormal eyelid development ( J:88776 )

• migration of eyelid epithelial cells appears to be defective

failure of eyelid fusion ( J:88776 )

• at E16.5, the upper and lower eyelids of wild-type embryos are fused in the midline, whereas those of heterozygous mutant embryos remain far apart due to defective migration of eyelid epithelial cells

eyelids open at birth ( J:88776 )

• heterozygotes are born with eyelids open, whereas the eyelids of wild-type littermates remain closed until 12 days after birth

cellular

decreased fibroblast cell migration ( J:88776 )

• in vitro, mouse embryonic fibroblasts (MEFs) isolated from heterozygous embryos show ~47% reduction in their migratory ability relative to wild-type MEFs

growth/size/body

weight loss ( J:166602 )

• significant weight loss is observed with addition of 2% dextran sodium sulfate (DSS) to water, suggesting susceptibility to induced colitis

integument

plush coat ( J:88776 )

• coats have a velvet-like texture

waved hair ( J:88776 )

• the first coat is wavy

abnormal hair follicle orientation ( J:88776 )

• after the first coat, pelage hair loses its waviness and appears disoriented, with individual shafts projecting in different directions

curly vibrissae ( J:88776 )

• heterozygotes are born with curly vibrissae