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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(CMV-Rpgr)1Tili
transgene insertion 1, Tiansen Li
MGI:3038604
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Rpgrtm1Tili/Rpgrtm1Tili
Tg(CMV-Rpgr)1Tili/0 		involves: 129S4/SvJae * C57BL/6 MGI:3038727
tg2
 		Tg(CMV-Rpgr)1Tili/Tg(CMV-Rpgr)1Tili involves: C57BL/6 MGI:3038724
tg3
 		Tg(CMV-Rpgr)1Tili/0 involves: C57BL/6 MGI:3038725


Genotype
MGI:3038727
cx1
Allelic
Composition		 Rpgrtm1Tili/Rpgrtm1Tili
Tg(CMV-Rpgr)1Tili/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rpgrtm1Tili mutation (0 available); any Rpgr mutation (10 available)
Tg(CMV-Rpgr)1Tili mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
retina degeneration ( J:87299 )
• retinal degeneration occurs very rapidly
• 50% of photoreceptors are lost by 40 days of age as opposed to 2 years for Rpgr null homozygotes
abnormal eye physiology ( J:87299 )
• dark adapted rod EGRs were reduced at 40 days of age

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
X-linked cone-rod dystrophy 1 DOID:0111008 OMIM:304020
 J:87299




Genotype
MGI:3038724
tg2
Allelic
Composition		 Tg(CMV-Rpgr)1Tili/Tg(CMV-Rpgr)1Tili
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
retina degeneration ( J:87299 )
• retinal degeneration occurs more rapidly than in hemizygous mice




Genotype
MGI:3038725
tg3
Allelic
Composition		 Tg(CMV-Rpgr)1Tili/0
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
retina degeneration ( J:87299 )
• retinal degeneration occurs very rapidly
• 50% of photoreceptors are lost by 40 days of age
abnormal eye physiology ( J:87299 )
• dark adapted rod EGRs were reduced at 40 days of age




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory